Results 31 to 40 of about 1,834,397 (268)
FEBS Open Bio, 2022 Over the past few decades, dozens of in vitro methods have been developed to map, investigate and validate protein–protein interactions. However, most of these approaches are time‐consuming and labour‐intensive or require specialised equipment or ...
Zsuzsánna Réthi‐Nagy +2 more
doaj +1 more source
BMB Reports, 2003 Cancer is frequently considered to be a disease of the cell cycle. As such, it is not surprising that the deregulation of the cell cycle is one of the most frequent alterations during tumor development. Cell cycle progression is a highlyordered and tightly-regulated process that involves multiple checkpoints that assess extracellular growth signals ...
Moon-Taek, Park, Su-Jae, Lee
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Fly, 2007 Drosophila researchers met in sunny San Diego for the 49th annual meeting of The Genetics Society of America. It was cold outside and even colder inside. Like last year, ‘Mitosis, Meiosis and Cell Division’ was no longer a session. Instead, we searched out and covered talks and posters in ‘Cell Division and Growth Control’, ‘Gametogenesis ...
Kristin, Garcia +2 more
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Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle
Nature CommunicationsCell cycle events are ordered by cyclin-dependent kinases (CDKs), which phosphorylate hundreds of substrates. Multiple phosphatases oppose these CDK substrates, yet their collective role in regulating phosphorylation timing in vivo remains unclear. Here,
Theresa U. Zeisner +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Genome BiologyBackground The histone code, comprised of diverse histone post-translational modifications, intricately regulates nucleosome organization and gene expression. Histone marks also serve as binding sites for a diverse array of protein complexes and enzymes,
Rubén Barrios +7 more
doaj +1 more source
Deconstructing the cell cycle [PDF]
Nature Reviews Molecular Cell Biology, 2011 When I was an undergraduate student, knowing three key concepts would ensure success in 'Cell Cycle 101': that oscillations of cyclin–cyclin dependent kinase (CDK) complexes drive the cell cycle; that directionality is ensured by the irreversibility of periodic proteasome-mediated cyclin degradation; and that checkpoints ensure the dependence of later ...
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko +19 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Results of COG ANBL1221 changed treatment paradigms for patients with relapsed/refractory neuroblastoma. Chemoimmunotherapy with irinotecan/temozolomide/dinutuximab is now used as both bridge therapy following suboptimal response to induction and as treatment in first relapse.
Elizabeth Sokol +6 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan +15 more
wiley +1 more source