miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells
BMC Cancer, 2022 MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by ...
Garima Singh +2 more
doaj +1 more source
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
eLife, 2022 Spatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors.
Jérôme Lacoste +6 more
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ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2020 DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin +10 more
doaj +1 more source
Nature Communications, 2023 Cyclin-dependent kinase (Cdk) stimulates resection of DNA double-strand breaks ends to generate single-stranded DNA (ssDNA) needed for recombinational DNA repair.
Adrián Campos +7 more
doaj +1 more source
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
core +2 more sources
Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
Nature Communications, 2016 The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C ...
Francesco Meghini +6 more
doaj +1 more source
Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
BMC Biology, 2022 Background In many organisms, aging is characterized by a loss of mitochondrial homeostasis. Multiple factors such as respiratory metabolism, mitochondrial fusion/fission, or mitophagy have been linked to cell longevity, but the exact impact of each one ...
Montserrat Vega +6 more
doaj +1 more source
The role of the cell cycle machinery in resumption of postembryonic development [PDF]
, 2005 Cell cycle activity is required for plant growth and development, but its involvement in the early events that initiate seedling development remains to be clarified. We performed experiments aimed at understanding when cell cycle progression is activated
Barrôco, Rosa Maria +6 more
core +2 more sources
Conditional control of fluorescent protein degradation by an auxin-dependent nanobody
Nature Communications, 2018 Current approaches to conditionally deplete target proteins require site-specific genetic engineering or have poor temporal control. Here the authors overcome these limitations by combining the AID system with nanobodies to reversibly degrade GFP-tagged ...
Katrin Daniel +5 more
doaj +1 more source
IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis
iScience, 2020 Summary: The maintenance of the intestinal epithelium is ensured by the controlled proliferation of intestinal stem cells (ISCs) and differentiation of their progeny into various cell types, including enterocytes (ECs) that both mediate nutrient ...
Alexei Arnaoutov +7 more
doaj +1 more source