Results 11 to 20 of about 8,365,967 (315)
Cell Cycle Commitment and the Origins of Cell Cycle Variability [PDF]
Frontiers in Cell and Developmental Biology, 2021 Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a ...
Robert F. Brooks, Robert F. Brooks
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The Oncologist, 2000 The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
E D, Israels, L G, Israels
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 ‘Dividing cells pass through a regular sequence of cell growth and division, known as the cell cycle’, according to a college textbook of biology published in 1983 [[1][1]], 5 years before the underlying principles of control were first laid bare during 1988, the annus mirabilis of cell ...
Hunt, T, Nasmyth, K, Novák, B
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The Cell Cycle is a Limit Cycle [PDF]
Mathematical Modelling of Natural Phenomena, 2012 Progression along the successive phases of the mammalian cell cycle is driven by a network of cyclin-dependent kinases (Cdks). This network is regulated by a variety of negative and positive feedback loops. We previously proposed a detailed, 39-variable model for the Cdk network and showed that it is capable of temporal self-organization in the form of
Gérard, Claude, Goldbeter, Albert
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Epigenetics & Chromatin, 2022 Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro +5 more
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DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
Cell Death Discovery, 2023 Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan +9 more
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iScience, 2022 Summary: The MAP kinase Sty1 phosphorylates and activates the transcription factor Atf1 in response to several stress conditions, which then shifts from a transcriptional repressor to an activator.
Rodrigo Fraile +4 more
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Discover Oncology, 2023 Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integration into human
Garima Singh +3 more
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Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H. +9 more
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Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]
, 2010 Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Segref, Alexandra +9 more
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