Results 21 to 30 of about 3,524,174 (306)
The contribution of age structure to cell population responses to targeted therapeutics [PDF]
, 2012 Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner.
Ackleh +52 more
core +7 more sources
Nature Communications, 2016 The small molecule (p)ppGpp is commonly produced by bacteria as a signal of nutrient starvation. Here, Ronneau et al. show that (p)ppGpp accumulation in the model bacterium Caulobacter crescentusis modulated by a nitrogen-related phosphotransferase ...
Séverin Ronneau +3 more
doaj +1 more source
A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]
, 2008 A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza +7 more
core +1 more source
Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase
Communicative & Integrative Biology, 2016 Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α ...
François Beaufay +2 more
doaj +1 more source
Antioxidants, 2023 Aging is characterized by a number of hallmarks including loss of mitochondrial homeostasis and decay in stress tolerance, among others. Unicellular eukaryotes have been widely used to study chronological aging.
Anna Gröger +5 more
doaj +1 more source
The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]
, 2016 Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa +11 more
core +3 more sources
Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest [PDF]
, 2009 The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin or 400 ng/ml oxaliplatin respectively. A recovery period
Davey, Ross, Stordal, Britta
core +2 more sources
The Oncologist, 2000 The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
E D, Israels, L G, Israels
openaire +3 more sources
Redox Biology, 2020 Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s).
Luis Marte +5 more
doaj +1 more source
DYRK1A and the Cell Cycle [PDF]
, 2020 The ability to halt the cell cycle is critical for cells to maintain tissue and organ size, to suppress tumors and abnormal growth, and exists as a helpful mechanism to pause the cell cycle for DNA repair.
Byers, Holly +1 more
core +1 more source