Improving our mechanistic understanding of cell cycle dynamics [PDF]
, 2022 The mammalian cell cycle is regulated by a well-studied but complex biochemical reaction system. Computational models provide a particularly systematic and systemic description of the mechanisms governing mammalian cell cycle control.
Lang, Paul F
core +1 more source
Transcriptome changes and cAMP oscillations in an archaeal cell cycle [PDF]
, 2007 Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Jörg Soppa +8 more
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Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila
Nature Communications, 2022 The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear.
Pénélope Darnat +6 more
doaj +1 more source
Cell cycle length, cell size, and proliferation rate in hydra stem cells [PDF]
, 1990 We have analyzed the cell cycle parameters of interstitial cells in Hydra oligactis. Three subpopulations of cells with short, medium, and long cell cycles were identified. Short-cycle cells are stem cells; medium-cycle cells are precursors to nematocyte
Charles +4 more
core +1 more source
miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells
BMC Cancer, 2022 MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by ...
Garima Singh +2 more
doaj +1 more source
Nek family of kinases in cell cycle, checkpoint control and cancer [PDF]
, 2011 Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in ...
Haider Nasir +15 more
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Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
Nature Communications, 2016 The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C ...
Francesco Meghini +6 more
doaj +1 more source
ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2020 DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin +10 more
doaj +1 more source
Nature Communications, 2023 Cyclin-dependent kinase (Cdk) stimulates resection of DNA double-strand breaks ends to generate single-stranded DNA (ssDNA) needed for recombinational DNA repair.
Adrián Campos +7 more
doaj +1 more source
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
eLife, 2022 Spatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors.
Jérôme Lacoste +6 more
doaj +1 more source