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Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology, 2003Although toxicants may initiate cell damage or stress, the cellular proteins that are involved in control of cell cycle and apoptosis are the final arbiters of cell fate. The biochemical pathways that restrain cell cycle transition and/or induce cell death after stress are known as cell cycle checkpoints.
J A, Pietenpol, Z A, Stewart
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TGF-β: receptors and cell cycle arrest
Molecular and Cellular Endocrinology, 1996Transforming growth factor-beta (TGF-beta) is the prototypic member of a superfamily of proteins important in normal growth and development. The recent molecular cloning and characterization of TGF-beta receptors represents a major advance in our understanding of the mechanism of action of this cytokine.
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Mechanisms of TGF-β-Induced Cell Cycle Arrest
Mineral and Electrolyte Metabolism, 1998Mitogenic growth factors stimulate cell growth by initiating a signaling cascade leading to the activation of the cyclin-dependent kinases (cdks), phosphorylation of pRb, and subsequent entry of the cell into the S phase. Transforming growth factor-β (TGF-β) is a potent antimitogen in a wide variety of cells and is postulated to inhibit cell cycle ...
B A, Hocevar, P H, Howe
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Chemically Induced Cell Cycle Arrest in Perfusion Cell Culture
2016In contrast to most present methods, continuous imaging of live cells would require full automation in each processing step. As an integrated system that would meet all requirements does not exist, we have established a long-term scanning-perfusion platform that: (a) replaces old medium with fresh one, (b) bypasses physical contact with the cell ...
Gabor, Nagy +4 more
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Cell cycle checkpoints: Arresting progress in mitosis
BioEssays, 1997AbstractCell cycle arrest in M phase can be induced by the failure of a single chromosome to attach properly to the mitotic spindle. The same cell cycle checkpoint mediates M phase arrest when cells are treated with drugs that either disrupt or hyperstabilize spindle microtubules.
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Arresting developments in cell-cycle control
Trends in Biochemical Sciences, 1994openaire +2 more sources