Results 91 to 100 of about 812,761 (308)
Exploring the underlying mechanisms of Xenopus laevis embryonic cell cycle [PDF]
arXiv, 2017 Cell cycle is an indispensable process in the proliferation and development. Despite significant efforts, global quantification and physical understanding are still challenging. In this study, we explored the mechanisms of Xenopus laevis embryonic cell cycle by quantifying the underlying landscape and flux.
arxiv
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
The Plant Cell, 2012 This article examines aluminum (Al) toxicity, finding that root growth arrest is an active process requiring two cell-cycle checkpoint regulators that monitor DNA damage; this indicates that Al may induce DNA damage, thereby triggering root growth arrest.
Cynthia D. Nezames +3 more
semanticscholar +1 more source
Checkpoint Placement for Systematic Fault-Injection Campaigns [PDF]
arXiv, 2023 Shrinking hardware structures and decreasing operating voltages lead to an increasing number of transient hardware faults,which thus become a core problem to consider for safety-critical systems. Here, systematic fault injection (FI), where one program-under-test is systematically stressed with faults, provides an in-depth resilience analysis in the ...
arxiv
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Can eukaryotic cells monitor the presence of unreplicated DNA?
Cell Division, 2007 Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow time for those
Aragón Luis +2 more
doaj +1 more source
DNA damage responses in human induced pluripotent stem cells and embryonic stem cells. [PDF]
PLoS ONE, 2010 Induced pluripotent stem (iPS) cells have the capability to undergo self-renewal and differentiation into all somatic cell types. Since they can be produced through somatic cell reprogramming, which uses a defined set of transcription factors, iPS cells ...
Olga Momcilovic +5 more
doaj +1 more source
Methotrexate increases expression of cell cycle checkpoint genes via JNK activation.
Arthritis & Rheumatism, 2012 OBJECTIVE To assess defects in expression of critical cell cycle checkpoint genes and proteins in patients with rheumatoid arthritis (RA) relative to presence or absence of methotrexate (MTX) treatment, and to investigate the role of JNK in induction of ...
Charles F. Spurlock +4 more
semanticscholar +1 more source