Results 241 to 250 of about 812,761 (308)

DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion. [PDF]

Cell Cycle, 2018
Misenko SM, Patel DS, Her J, Bunting SF.
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source

Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition. [PDF]

Cancer Treat Rev, 2018
Haynes B, Murai J, Lee JM.
europepmc   +1 more source

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, EarlyView.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang, Zhengren Xu, Wei Wang, Haihua Xiao, Zhiqiang Lin, Hongbin Han   +14 more
wiley   +1 more source

Proteomics‐Empowered Microfluidic‐SERS Immunoassay for Identifying and Detecting Biomarkers of Micropapillary Lung Adenocarcinoma

Advanced Science, EarlyView.
The presence of a micropapillary (MPP) component is critical for lung adenocarcinoma (LUAD) surgery, yet reliable blood biomarkers remain lacking. This study integrates proteomics for biomarker identification, a nanomixing‐enhanced surface‐enhanced Raman spectroscopy (SERS) platform for sensitive detection, and machine learning for accurate ...
Dechun Zhang, Kaiming Peng, Hui Xu, Yanping Chen, Jing Wang   +4 more
wiley   +1 more source

Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration. [PDF]

Cell Prolif, 2018
Viswanathan P, Sharma Y, Gupta P, Gupta S.   +3 more
europepmc   +1 more source