Results 261 to 270 of about 812,761 (308)

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

Advanced Science, EarlyView.
This study employs neutrophils for the precise delivery of anti‐CD47 antibodies, combined with bacterial outer membrane vesicles, to enhance macrophage phagocytic function in the tumor microenvironment. This approach effectively activates T‐cell anti‐tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and ...
Meng Guan, Xiao‐Ting Xie, Dong Zhou, Kai Cheng, Bin Zhang, Xin‐Yue Xu, Yong Li, Yi‐Tong Zhou, Wei Peng, Li‐Li Chen, Peng‐Shuo Dong, Si Chen, Jia‐Hua Zou, Bo Liu, Yuan‐Di Zhao, Jin‐Xuan Fan   +15 more
wiley   +1 more source

Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells

Annals of Gastroenterological Surgery, EarlyView.
Blue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Masaaki Nishi, Chiharu Nakasu, Toshiaki Yoshimoto, Takuya Tokunaga, T. Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada, Mitsuo Shimada   +8 more
wiley   +1 more source

Role of radiotherapy in surgical approaches to pancreatic cancer treatment: A narrative review

Annals of Gastroenterological Surgery, EarlyView.
This review explores the role of radiotherapy (RT) in the multidisciplinary treatment of pancreatic ductal adenocarcinoma (PDAC), focusing on its integration with surgical strategies to improve resectability, local control, and survival outcomes while addressing potential challenges and future research directions.
Satoshi Yasuda, Minako Nagai, Kota Nakamura, Yasuko Matsuo, Masayuki Sho   +4 more
wiley   +1 more source

Cell-cycle checkpoints and cancer [PDF]

Nature, 2004
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical ...
Jiri Bartek, Michael B. Kastan
openaire   +3 more sources

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Cell cycle checkpoint control in response to dna damage by environmental stresses.

The Plant Journal, 2021
Being sessile organisms, plants are ubiquitously exposed to stresses that can affect the DNA replication process or cause DNA damage. To cope with these problems, plants utilize DNA damage response (DDR) pathways, consisting of both highly conserved and ...
J. Pedroza-García, Yanli Xiang, L. De Veylder   +2 more
semanticscholar   +1 more source

CYCLINS AND CELL CYCLE CHECKPOINTS

Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract  The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several ...
Cheryl L. Walker, David G. Johnson
openaire   +3 more sources

Cell cycle checkpoints in bacteria

Biochimie, 1997
When DNA replication is interrupted in bacteria, a specific inhibitor (SfiA), a component of the SOS system, is synthesised which transiently blocks cell division. This is the prototype, dispensable, cell cycle checkpoint, essential for maximal survival under a particular stress.
S. J. Séror, A. Levine, S. Autret, I.B. Holland   +3 more
openaire   +3 more sources

Cell cycle checkpoints

Current Opinion in Cell Biology, 1994
Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA.
openaire   +3 more sources

Cell Cycle Checkpoints [PDF]

, 2000
In eukaryotic cells, cell division proceeds through an orderly series of events in which the cellular contents are duplicated, divided, and distributed to daughter cells. This progression through the cell cycle is governed by the sequential activation and inactivation of members of a family of serine/threonine kinases known as the Cdks (cyclin ...
openaire   +1 more source