Results 271 to 280 of about 812,761 (308)

The genetics of cell cycle checkpoints

Current Opinion in Genetics & Development, 1995
Checkpoints help in the prevention of genetic damage by giving cells time to repair damaged structures before proceeding in the cell cycle. Genetic analyses in budding and fission yeast have identified a large number of cell cycle checkpoint genes. Several of these encode proteins related to components of other signal transduction pathways, including ...
openaire   +3 more sources

Cell Cycle Checkpoints

2013
In this entry we describe the molecular mechanisms of the cell cycle checkpoints. We focused our attention on the DNA damage checkpoint and on the spindle assembly and spindle positioning checkpoints, controlling chromosome segregation in mitosis.
M. Muzi Falconi, P. Plevani, F. Amara
openaire   +2 more sources

The Cell Cycle: Accelerators, Brakes, and Checkpoints

Neurosurgery, 2004
PROLIFERATIVE CUES TRIGGER a complex series of molecular signaling events in cells. Early in the cell cycle, cells are faced with an important decision that affects their fate. They either initiate a round of replication or they withdraw from cell division.
James T. Rutka, Stacey Ivanchuk
openaire   +2 more sources

DNA damage and cell cycle checkpoints

The FASEB Journal, 1996
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division.
William K. Kaufmann, Richard S. Paules
openaire   +3 more sources

Checkpoints in the cell cycle of fission yeast

Current Opinion in Genetics & Development, 1995
When cell cycle progression in fission yeast is disrupted, checkpoint controls ensure that the normal sequence of cell cycle events is maintained. Activation of a checkpoint relies on monitoring signals that might involve assembly of macromolecular structures essential for specific cell cycle processes. The past year has seen further elucidation of two
Paul Nurse, Gennaro D'Urso
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Cell-cycle checkpoint kinases: checking in on the cell cycle

Current Opinion in Cell Biology, 2000
In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice.
openaire   +3 more sources

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma

Pigment Cell & Melanoma Research, 2013
The ultraviolet radiation (UVR) component of sunlight is the major environmental risk factor for melanoma, producing DNA lesions that can be mutagenic if not repaired. The high level of mutations in melanomas that have the signature of UVR‐induced damage
S. Pavey, L. Spoerri, N. Haass, B. Gabrielli   +3 more
semanticscholar   +1 more source

Cell cycle checkpoint signaling:

Toxicology, 2002
Although toxicants may initiate cell damage or stress, the cellular proteins that are involved in control of cell cycle and apoptosis are the final arbiters of cell fate. The biochemical pathways that restrain cell cycle transition and/or induce cell death after stress are known as cell cycle checkpoints.
Jennifer A. Pietenpol, Zoe A. Stewart
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An additional cell cycle checkpoint

Science, 2018
Molecular Biology Cell division is controlled by checkpoints that regulate the temporal order of the cell cycle phases, including the G1/S, G2/M, and metaphase/anaphase transitions. Yet there are no known control mechanisms for a fourth fundamental transition—the S/G2 transition. Saldivar et al.
openaire   +2 more sources

Regulation of RAD53 by the ATM-Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

Science, 1996
Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated (ATM) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced.
Y. Sánchez, B. Desany, William J. Jones, Qinghua Liu, Bin Wang, S. Elledge   +5 more
semanticscholar   +1 more source