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Cell Cycle Checkpoints and Senescence
2016Cellular senescence, an outcome of finite proliferative, limited repair and defence capacity of normal cells, is a widely accepted in vitro model for ageing studies. In a sharp contrast to cancer cells, it is firmly regulated by cell cycle checkpoints that ensure evasion of stressed and genetically modified cells, limiting their expansion and serve as ...
Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul
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A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
The FASEB Journal, 1997Computer analysis of a conserved domain, BRCT, first described at the carboxyl ter‐minus of the breast cancer protein BRCA1, a p53 binding protein (53BP1), and the yeast cell cycle checkpoint protein RAD9 revealed a large super‐ family of domains that ...
P. Bork +5 more
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The Cell Cycle, Cyclins, Checkpoints and Cancer
Asian Journal of Research in Pharmaceutical Sciences, 2021Cancer is a serious problem affecting the health of human and isone of the leading cause of mortality worldwide. A normal cell undergoes regulated cell division, differentiation and apoptosis (programmed cell death). When normal cell has lost the usual control over their division, differentiation and apoptosis they become tumor cells.
Farha Fatma, Anil Kumar
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Extinguishing a Cell Cycle Checkpoint
Science, 2006The steps in cell division are precisely orchestrated. A key checkpoint is inactivated after it has performed its function so that the next steps can take place.
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Cell-Cycle Checkpoints in a State Network
Journal of the Korean Physical Society, 2008The sequence of cell-cycle activities can be seen as a dynamic flow in a state space (SS) that is composed of the Boolean states. Here, we propose a mathematical method to identify the checkpoint proteins through topological features of the network defined in SS. The checkpoint provides a cell with recovery time by arresting the cell-cycle process when
Eunsoon Oh, J. S. Lee, Byungnam Kahng
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regulation of the cell cycle cell cycle checkpoints and cancer
2005DNA damage response (DDR) pathways are triggered to ensure proper repair of DNA lesions and preserve genome integrity. Key intracellular transducers of the DNA damage are ataxia-telangiectasia mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR).
Delia D., Buscemi G.
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Neuronal apoptosis at the G1/S cell cycle checkpoint
Cell and Tissue Research, 2001Apoptosis is a fundamental and essential process in development and tissue homeostasis of multicellular organisms. Roughly half of all the neurons produced during neurogenesis die apoptotically before the nervous system matures. Apoptosis is also involved in various neurodegenerative disorders such as Alzheimer's disease and neuronal trauma ...
David Liu, Lloyd A. Greene
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Cell cycle checkpoints as therapeutic targets.
Journal of mammary gland biology and neoplasia, 1999Most human breast tumors arise from multiple genetic changes which gradually transform differentiated and growth-limited cells into highly invasive cells that are unresponsive to growth controls. The genetic evolution of normal breast cells into cancer cells is largely determined by the fidelity of DNA replication, repair, and division.
Jennifer A. Pietenpol, Zoe A. Stewart
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Cell Cycle Checkpoints and Cancer Chemotherapy
1996The majority of anticancer agents in current clinical practice arrest cell cycle progression at one or more definable points (Table 1). The DNA damaging agents including, bleomycin, adriamycin, etoposide, nitrogen mustards and cisplatin, arrest cell cycle progression in G1 and/or G2 phases. These agents can also prolong S phase progression.
Saijun Fan, Patrick M. O'Connor
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