Results 281 to 290 of about 775,653 (341)
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2000
In eukaryotic cells, cell division proceeds through an orderly series of events in which the cellular contents are duplicated, divided, and distributed to daughter cells. This progression through the cell cycle is governed by the sequential activation and inactivation of members of a family of serine/threonine kinases known as the Cdks (cyclin ...
Kristi Chrispell Forbes, Tamar Enoch
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In eukaryotic cells, cell division proceeds through an orderly series of events in which the cellular contents are duplicated, divided, and distributed to daughter cells. This progression through the cell cycle is governed by the sequential activation and inactivation of members of a family of serine/threonine kinases known as the Cdks (cyclin ...
Kristi Chrispell Forbes, Tamar Enoch
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2013
In this entry we describe the molecular mechanisms of the cell cycle checkpoints. We focused our attention on the DNA damage checkpoint and on the spindle assembly and spindle positioning checkpoints, controlling chromosome segregation in mitosis.
M. Muzi Falconi, P. Plevani, F. Amara
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In this entry we describe the molecular mechanisms of the cell cycle checkpoints. We focused our attention on the DNA damage checkpoint and on the spindle assembly and spindle positioning checkpoints, controlling chromosome segregation in mitosis.
M. Muzi Falconi, P. Plevani, F. Amara
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CYCLINS AND CELL CYCLE CHECKPOINTS
Annual Review of Pharmacology and Toxicology, 1999▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several ...
D G, Johnson, C L, Walker
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Cell cycle checkpoints in bacteria
Biochimie, 1997When DNA replication is interrupted in bacteria, a specific inhibitor (SfiA), a component of the SOS system, is synthesised which transiently blocks cell division. This is the prototype, dispensable, cell cycle checkpoint, essential for maximal survival under a particular stress.
S, Autret +3 more
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Cell Cycle Checkpoints as Therapeutic Targets
Journal of Mammary Gland Biology and Neoplasia, 1999Most human breast tumors arise from multiple genetic changes which gradually transform differentiated and growth-limited cells into highly invasive cells that are unresponsive to growth controls. The genetic evolution of normal breast cells into cancer cells is largely determined by the fidelity of DNA replication, repair, and division.
Z A, Stewart, J A, Pietenpol
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DNA damage and cell cycle checkpoints
The FASEB Journal, 1996DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division.
W K, Kaufmann, R S, Paules
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Cell cycle: Checkpoint Pathways
Science's STKE, 1999The checkpoint mechanism by which budding yeast Saccharomyces cerevisiae achieve mitotic arrest in response to DNA damage has been studied by Sanchez et al . In mammalian cells and the fission yeast Saccharomyces pombe , DNA damage causes arrest through inhibitory ...
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Cell cycle: Checkpoint Maintenance
Science Signaling, 1999The once inexplicable actions of 14-3-3 proteins gradually become clearer. Members of this protein family bind to phosphorylated proteins and appear to prevent their movement to the nucleus. Chan et al. made human colorectal cancer cells that lacked expression of a particular 14-3-3 protein, 14-3-3sigma. These cells
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The genetics of cell cycle checkpoints
Current Opinion in Genetics & Development, 1995Checkpoints help in the prevention of genetic damage by giving cells time to repair damaged structures before proceeding in the cell cycle. Genetic analyses in budding and fission yeast have identified a large number of cell cycle checkpoint genes. Several of these encode proteins related to components of other signal transduction pathways, including ...
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Studying Cell Cycle Checkpoints Using Drosophila Cultured Cells
2011Drosophila cell lines are valuable tools to study a number of cellular processes, including DNA damage responses and cell cycle checkpoint control. Using an in vitro system instead of a whole organism has two main advantages: it saves time and simple and effective molecular techniques are available. It has been shown that Drosophila cells, similarly to
Siudeja, Katarzyna +2 more
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