Results 51 to 60 of about 812,761 (308)
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Cells need to rapidly control their cell cycle profile, gene expression, or protein stability in response to the activation of stress-response pathways.
Keiko Kono +4 more
semanticscholar +1 more source
Gene Copy Number and Cell Cycle Arrest [PDF]
, 2005 The cell cycle is an orderly sequence of events which ultimately lead to the division of a single cell into two daughter cells. In the case of DNA damage by radiation or chemicals, the damage checkpoints in the $G_{1}$ and $G_{2}$ phases of the cell cycle are activated. This results in an arrest of the cell cycle so that the DNA damage can be repaired.
arxiv +1 more source
Critical slowing down and attractive manifold: a mechanism for dynamic robustness in yeast cell-cycle process [PDF]
Phys. Rev. E 101, 042405 (2020), 2018 The biological processes that execute complex multiple functions, such as cell cycle, must ensure the order of sequential events and keep the dynamic robustness against various fluctuations. Here, we examine the dynamic mechanism and the fundamental structure to achieve these properties in the cell-cycle process of budding yeast Saccharomyces ...
arxiv +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
BMC Cell Biology, 2005 Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
doaj +1 more source
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer [PDF]
Cancer Research, 2005 Abstract It has been reported that disruption of the circadian clock may lead to increased risk of breast cancer in humans and to a high rate or ionizing radiation–induced tumors and mortality in mice. Cryptochrome 1 and cryptochrome 2 proteins are core components of the mammalian circadian clock and mice mutated in both genes are ...
Michele A. Gauger, Aziz Sancar
openaire +3 more sources
bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast
Frontiers in Oncology, 2012 Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen +5 more
doaj +1 more source
A checkpoint-oriented cell cycle simulation model [PDF]
Cell Cycle, 2019 Modeling and in silico simulations are of major conceptual and applicative interest in studying the cell cycle and proliferation in eukaryotic cells. In this paper, we present a cell cycle checkpoint-oriented simulator that uses agent-based simulation modeling to reproduce the dynamics of a cancer cell population in exponential growth.
Bernard, David +6 more
openaire +6 more sources
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control
Nature Communications, 2015 Cells respond to DNA damage by activating cell cycle checkpoints to delay proliferation and facilitate DNA repair. Here, to uncover new checkpoint regulators, we perform RNA interference screening targeting genes involved in ubiquitylation processes.
Ditte K. Klein +15 more
semanticscholar +1 more source
The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
Cancer Cell International, 2020 One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasive, metastatic, drug-resistance, and anti ...
Kai Liu +7 more
semanticscholar +1 more source