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Topoisomerase II Inhibitors and Poisons, and the Influence of Cell Cycle Checkpoints
Current Medicinal Chemistry, 2017 Interactions between the decatenation checkpoint and Topoisomerase II (TopoII) are vital for maintaining integrity of the genome. Agents that target this enzyme have been in clinical use in cancer therapy for over 30 years with great success.
Brian Gabrielli
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Cell cycle checkpoints in bacteria
Biochimie, 1997When DNA replication is interrupted in bacteria, a specific inhibitor (SfiA), a component of the SOS system, is synthesised which transiently blocks cell division. This is the prototype, dispensable, cell cycle checkpoint, essential for maximal survival under a particular stress.
S, Autret +3 more
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CYCLINS AND CELL CYCLE CHECKPOINTS
Annual Review of Pharmacology and Toxicology, 1999▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several ...
D G, Johnson, C L, Walker
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Cell-cycle checkpoints and cancer
Nature, 2004All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical ...
Michael B, Kastan, Jiri, Bartek
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2000
Abstract During each yeast cell cycle, chromosomes must be copied faithfully and segregated accurately between daughter cells. Surveillance systems termed ‘checkpoints’ ensure the fidelity of chromosome duplication by detecting abnormal structures and blocking cell cycle transitions while problems are corrected.
Kristi Chrispell Forbes, Tamar Enoch
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Abstract During each yeast cell cycle, chromosomes must be copied faithfully and segregated accurately between daughter cells. Surveillance systems termed ‘checkpoints’ ensure the fidelity of chromosome duplication by detecting abnormal structures and blocking cell cycle transitions while problems are corrected.
Kristi Chrispell Forbes, Tamar Enoch
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, 2005 细胞周期是高度有组织的时序调控过程,受到DNA损伤检控点、DNA复制检控点和纺锤体检控点等细胞周期检控点的精确调控。细胞周期检控点的作用主要是调节细胞周期的时序转换,以确保DNA复制、染色体分离等细胞重要生命活动的高度精确性,并对DNA损伤、DNA复制受阻、纺锤体组装和染色体分离异常等细胞损伤及时做出反应,以防止突变和遗传不稳定的发生。细胞周期检控点的功能缺陷,将导致细胞基因组的不稳定,与细胞癌变密切相关 ...
鲍仕登 +3 more
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The genetics of cell cycle checkpoints
Current Opinion in Genetics & Development, 1995Checkpoints help in the prevention of genetic damage by giving cells time to repair damaged structures before proceeding in the cell cycle. Genetic analyses in budding and fission yeast have identified a large number of cell cycle checkpoint genes. Several of these encode proteins related to components of other signal transduction pathways, including ...
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