Results 241 to 250 of about 6,549,693 (278)

The Caulobacter cell cycle: timing, spatial organization and checkpoints

Current Opinion in Microbiology, 2002
In Caulobacter crescentus, a complex regulatory network integrates temporal and spatial information to control the ordered progression of the cell cycle, and to synchronize cell proliferation with development.
Craig Stephens, Urs Jenal
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Cell-cycle checkpoint kinases: checking in on the cell cycle

Current Opinion in Cell Biology, 2000
In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice.
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Cell Cycle Checkpoints as Therapeutic Targets

Journal of Mammary Gland Biology and Neoplasia, 1999
Most human breast tumors arise from multiple genetic changes which gradually transform differentiated and growth-limited cells into highly invasive cells that are unresponsive to growth controls. The genetic evolution of normal breast cells into cancer cells is largely determined by the fidelity of DNA replication, repair, and division.
Z A, Stewart, J A, Pietenpol
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The Cell Cycle: Accelerators, Brakes, and Checkpoints

Neurosurgery, 2004
PROLIFERATIVE CUES TRIGGER a complex series of molecular signaling events in cells. Early in the cell cycle, cells are faced with an important decision that affects their fate. They either initiate a round of replication or they withdraw from cell division.
Stacey M, Ivanchuk, James T, Rutka
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DNA damage and cell cycle checkpoints

The FASEB Journal, 1996
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division.
W K, Kaufmann, R S, Paules
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Cell Cycle Checkpoints and Senescence

2016
Cellular senescence, an outcome of finite proliferative, limited repair and defence capacity of normal cells, is a widely accepted in vitro model for ageing studies. In a sharp contrast to cancer cells, it is firmly regulated by cell cycle checkpoints that ensure evasion of stressed and genetically modified cells, limiting their expansion and serve as ...
Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul
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Regulation of the Cell Cycle, Cell Cycle Checkpoints and Cancer

2005
DNA damage response (DDR) pathways are triggered to ensure proper repair of DNA lesions and preserve genome integrity. Key intracellular transducers of the DNA damage are ataxia-telangiectasia mutated kinase (ATM) and ataxia-telangiectasia and Rad3-related kinase (ATR).
Delia D., Buscemi G.
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Cell cycle: Checkpoint Pathways

Science's STKE, 1999
The checkpoint mechanism by which budding yeast Saccharomyces cerevisiae achieve mitotic arrest in response to DNA damage has been studied by Sanchez et al . In mammalian cells and the fission yeast Saccharomyces pombe , DNA damage causes arrest through inhibitory ...
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Cell Cycle Checkpoints

2021
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An additional cell cycle checkpoint

Science, 2018
Molecular Biology Cell division is controlled by checkpoints that regulate the temporal order of the cell cycle phases, including the G1/S, G2/M, and metaphase/anaphase transitions. Yet there are no known control mechanisms for a fourth fundamental transition—the S/G2 transition. Saldivar et al.
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