Results 101 to 110 of about 3,883,823 (304)

The ubiquitin-proteasome system in glioma cell cycle control

Cell Division, 2012
A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors.
Vlachostergios Panagiotis J, Voutsadakis Ioannis A, Papandreou Christos N   +2 more
doaj   +1 more source

Dynamics of cell cycle proteins involved in Toxoplasma gondii-induced bovine NET formation. [PDF]

Front Immunol, 2023
Velásquez ZD, Peixoto R, Gärtner U, Hermosilla C, Taubert A, Conejeros I.   +5 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

TAF15 mediates ROP16-induced apoptosis and cell cycle arrest in lung cancer

Parasites & Vectors
Objective This study aimed to investigate the effects of the interaction between ROP16 and TAF15 on apoptosis and cell cycle regulation in A549 lung adenocarcinoma cells.
Guangqi Li, Mei Tian, Yuning Zhou, Shaohan Ma, Shanni Ma, Qirui Ge, Zhijun Zhao   +6 more
doaj   +1 more source

Yeast UBL-UBA proteins have partially redundant functions in cell cycle control

Cell Division, 2006
Background Proteins containing ubiquitin-like (UBL) and ubiquitin associated (UBA) domains have been suggested to shuttle ubiquitinated substrates to the proteasome for degradation. There are three UBL-UBA containing proteins in budding yeast: Ddi1, Dsk2
Clarke Duncan J, Walters Kylie J, Kang Yang, Díaz-Martínez Laura A   +3 more
doaj   +1 more source

Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images. [PDF]

PLoS Comput Biol, 2022
Pécot T, Cuitiño MC, Johnson RH, Timmers C, Leone G.   +4 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell Cycle Arrest is a Conserved Function of Norovirus VPg Proteins

Viruses, 2019
Murine norovirus (MNV) viral protein genome-linked (VPg) manipulates the cell cycle to induce a G0/G1 arrest and gain a beneficial replication environment.
Alice McSweeney, Colin Davies, Vernon K. Ward   +2 more
doaj   +1 more source

Curcumin Sensitises Cancerous Kidney Cells to TRAIL Induced Apoptosis via Let-7C Mediated Deregulation of Cell Cycle Proteins and Cellular Metabolism. [PDF]

Int J Mol Sci, 2022
Obaidi I, Blanco Fernández A, McMorrow T.   +2 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source