The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process [PDF]
, 2006 Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases.
Baehrecke, Eric H. +8 more
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LOSS OF DIFFERENTIATING NEMATOCYTES INDUCED BY REGENERATION AND WOUND HEALING IN HYDRA [PDF]
, 1984 Cell death was observed in the nematocyte differentiation pathway in Hydra during head and foot regeneration. This death occurs throughout the regenerating piece, is transient in nature and is selective for committed stenotele and desmoneme precursors ...
David, Charles N., Fujisawa, Toshitaka
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Autophagy ReportsDisrupted intestinal homeostasis and barrier function contribute to the development of diseases such as inflammatory bowel disease. BECLIN-1, a core component of two class III phosphatidylinositol 3 kinase complexes, has a dual role in autophagy and ...
Juliani Juliani +10 more
doaj +1 more source
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Nature Communications, 2018 TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli +19 more
doaj +1 more source
Development of a Computational Model for Cell Activity in a Nano-Scaffold [PDF]
, 2020 Tissue engineering utilizes nano-scaffolds to direct cell growth and control cell behavior. Since cells occupy specific spaces within extracellular matrix (ECM) it’s important to understand how the geometry of these spaces influence cell behaviors such ...
Babcock, Ethan, Luke, Bethany
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The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM [PDF]
, 2000 The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate.
Hawkins, Christine J. +5 more
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Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia
Kinases and PhosphatasesT-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and ...
Claudina A. Pérez-Novo +6 more
doaj +1 more source
Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease
Hepatology Communications, 2018 Fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD).
Carmen García‐Ruiz +1 more
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How to Choose the Right Inducible Gene Expression System for Mammalian Studies?
Cells, 2019 Inducible gene expression systems are favored over stable expression systems in a wide variety of basic and applied research areas, including functional genomics, gene therapy, tissue engineering, biopharmaceutical protein production and drug discovery ...
Tuula Kallunki +3 more
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Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. [PDF]
, 1998 Recent studies have established cell type- specific, proapoptotic, or antiapoptotic functions for the transcription factor NF-kappaB. In each of these studies, inhibitors of NF-kappaB activity have been present before the apoptotic stimulus, and so the ...
DiDonato, JA +4 more
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