Results 131 to 140 of about 3,307,555 (359)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

How to Choose the Right Inducible Gene Expression System for Mammalian Studies?

open access: yesCells, 2019
Inducible gene expression systems are favored over stable expression systems in a wide variety of basic and applied research areas, including functional genomics, gene therapy, tissue engineering, biopharmaceutical protein production and drug discovery ...
Tuula Kallunki   +3 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding

open access: yesSignal Transduction and Targeted Therapy, 2021
Zubiao Niu   +9 more
doaj   +1 more source

Cell Death: A review

open access: yes, 2023
Cell death, a fundamental biological process, plays a crucial role in the development, maintenance, and overall functioning of multicellular organisms. While the term "cell death" might sound ominous, it is an essential mechanism that ensures the balance and homeostasis of cellular populations.
openaire   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Cell fusion in the pathogenesis of COVID-19

open access: yesMilitary Medical Research, 2021
You Zheng   +3 more
doaj   +1 more source

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