Results 141 to 150 of about 2,113,177 (314)
CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more sourceTransforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation
, 2001 In some situations, cell death in the nervous system is controlled by an interplay between survival factors and negative survival signals that actively induce apoptosis. The present work indicates that the survival of Schwann cells is regulated by such a Whitfield, J, Meier, C, Parkinson, DB, Jeesen, KR, Dong, ZP, Mirsky, R, Bunting, H, Marie, H +7 morecore Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceApoptotic cell death in disease : current understanding of the NCCD 2023
, 2023 Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this ...Kelly, Gemma L, Ghosh, Sourav, Vucic, Domagoj, Mastroberardino, Pier G, Altucci, Lucia, Elrod, John W, Galassi, Claudia, Garrido, Carmen, Lipton, Stuart A, Murphy, Daniel J, Verkhratsky, Alexei, Rodrigues, Cecilia M P, Novelli, Flavia, Broz, Petr, Szabadkai, Gyorgy, Villunger, Andreas, Green, Douglas R, Lemasters, John J, Conrad, Marcus, Sawa, Akira, Wang, Ruoning, Arama, Eli, Krysko, DmitriGE380020007704968010016119740000-0002-9692-2047F6642C16-F0ED-11E1-A9DE-61C894A0A6B4, Amelio, Ivano, Bove, Pierluigi, Del Sal, Giannino, Bortner, Carl D, Dawson, Ted M, Kepp, Oliver, Tang, Daolin, De Strooper, Bart, Damgaard, Rune Busk, Hengartner, Michael O, Kashkar, Hamid, Linkermann, Andreas, Mehlen, Patrick, Wood, Will, Zhou, Wenzhao, Ciliberto, Gennaro, MacFarlane, Marion, Penninger, Josef M, Guilbaud, Emma, Sun, Liming, Niklison-Chirou, Maria Victoria, Scorrano, Luca, Rajalingam, Krishnaraj, Robinson, Nirmal, Garg, Abhishek D, Mantovani, Roberto, Bartek, Jiri, Chen, Guo-Qiang, Oberst, Andrew, Barlev, Nickolai A, Becker, Christoph, Vander Heiden, Matthew G, Rudel, Thomas, Melino, Gerry, Marine, Jean-Christophe, Vanden Berghe, TomWE14001995143688801001388167F5D9F9A6-F0ED-11E1-A9DE-61C894A0A6B4, Tait, Stephen W G, Jost, Philipp J, Kaufmann, Thomas, Chen, Youhai H, Alnemri, Emad S, Hajnoczky, Gyorgy, Strapazzon, Flavie, Rizzuto, Rosario, Chen, Quan, Vanderluit, Jacqueline L, Joseph, Bertrand, Medema, Jan Paul, Tavernarakis, Nektarios, Cecconi, Francesco, Inoue, Satoshi, Stockwell, Brent R, Troy, Carol M, Sun, Qiang, Garcia-Saez, Ana J, Miao, Edward A, Ofengeim, Dimitry, Ciechanover, Aaron, Melino, Sonia, Agostinis, Patrizia, Peter, Marcus E, Madeo, Frank, Galluzzi, Lorenzo, Sun, Erwei, Puthalakath, Hamsa, Janic, Ana, Campanella, Michelangelo, Wallach, David, Martinou, Jean-Claude, Ricci, Jean-Ehrland, Lavandero, Sergio, Deberardinis, Ralph J, Malorni, Walter, Rubinsztein, David C, Zhivotovsky, Boris, Oren, Moshe, Urbano, Nicoletta, Simon, Hans-Uwe, Yamazaki, Takahiro, Turk, Boris, Manic, Gwenola, Vuri, Daniela, Rufini, Alessandro, Aqeilan, Rami I, Debatin, Klaus-Michael, Opferman, Joseph T, Munoz-Pinedo, Cristina, Piacentini, Mauro, Adam, Dieter, Wang, Ying, von Karstedt, Silvia, Zhang, Haibing, Carbone, Michele, Pagano, Michele, Hildeman, David A, Daugaard, Mads, De Maria, Ruggero, Lockshin, Richard A, He, Sudan, Schroder, Kate, Pasparakis, Manolis, Yang, Huang-Tian, Hacker, Georg, Nunez, Gabriel, Blomgren, Klas, Boya, Patricia, Zawacka-Pankau, Joanna E, Andrews, David W, Sesti, Federico, Vitale, Ilio, Hardwick, J Marie, Zhang, Lin, Sayan, Emre, Zakeri, Zahra, Klionsky, Daniel J, Bano, Daniele, Diederich, Marc, Bernassola, Francesca, Silke, John, Fimia, Gian Maria, Strasser, Andreas, Vousden, Karen H, Karin, Michael, Bianchi, Marco E, Liccardi, Gianmaria, Ganini, Carlo, Engeland, Kurt, Panaretakis, Theocharis, Calin, George A, Kumar, Sharad, Ravichandran, Kodi S, Pereira, David M, Prehn, Jochen H M, Kroemer, Guido, Marchi, Saverio, Rotblat, Barak, D'Angiolella, Vincenzo, Hetz, Claudio, Dynlacht, Brian D, Voss, Anne K, Blander, J Magarian, Aaronson, Stuart A, Bazan, Nicolas G, Chipuk, Jerry E, Kulms, Dagmar, Jaattela, Marja, El-Deiry, Wafik S, Lavrik, Inna N, Cubillos-Ruiz, Juan R, Czabotar, Peter E, Luedde, Tom, Blagosklonny, Mikhail V, Chan, Francis K-M, Dawson, Valina L, Pinton, Paolo, Porta, Giovanni, Haupt, Ygal, Brunner, Thomas, Kitsis, Richard N, Ryan, Kevin M, Sistigu, Antonella, Baehrecke, Eric H, Cheng, Emily H, Dixon, Scott J, Kluck, Ruth, Carmona-Gutierrez, Didac, Ichijo, Hidenori, Pentimalli, Francesca, Balachandran, Siddharth, Bertrand, MathieuWE140001614180038020005477810000-0001-9000-062601661B60-F0EE-11E1-A9DE-61C894A0A6B4, Kimchi, Adi, Pervaiz, Shazib, Kanneganti, Thirumala-Devi, Greene, Lloyd A, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, Degterev, Alexei, Stephanou, Anastasis, Sica, Giuseppe S, Lopez-Otin, Carlos, Moll, Ute M, Abrams, John M, Wagner, Erwin F, Blandino, Giovanni, Brenner, Catherine, Martin, Seamus J, Gronemeyer, Hinrich, Gavathiotis, Evripidis, Heery, David M, Rothlin, Carla V, Rehm, Markus, Sarosiek, Kristopher A, Shao, Feng, Meier, Pascal, Borner, Christoph, Candi, Eleonora, Walczak, Henning, Cidlowski, John A, Deshmukh, Mohanish, Pietrocola, Federico, Rabinovich, Gabriel A, Di Virgilio, Francesco, Gerlic, Motti, Agostini, Massimiliano, Shi, Yufang, Weber, Achim +227 morecore Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceAdaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová +10 morewiley +1 more sourceLipid peroxidation is essential for α-synuclein-induced cell death.
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.Klenerman, D, Shchepinov, MS, Gandhi, S, Angelova, PR, Horrocks, MH, Abramov, AY +5 morecore Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.
, 2009 International audienceDifferent types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms.Lipton, SA, Hengartner, M., Green, D. R., M E Peter, M Piacentini, El-Deiry, WS, Knight, RA, Blagosklonny, M. V., E H Baehrecke, J Abrams, Galluzzi, L., S A Lipton, Malorni, W, Abrams, J, Melino, G., P Vandenabeele, Kumar, S., L Galluzzi, W Malorni, Blagosklonny, MV, S Kumar, G Kroemer, Golstein, P, Nunez, G, Melino, G, Tschopp, J., Kroemer, G., Yuan, J., P Golstein, Vandenabeele, P., Abrams, J., Kroemer, G, Tschopp, J, Alnemri, ES, M Hengartner, Baehrecke, E. H., Peter, ME, R A Knight, Vandenabeele, Peter, Zhivotovsky, B, El-Deiry, W. S., Baehrecke, EH, Lipton, S. A., J Yuan, G Melino, J Tschopp, Alnemri, Emad, S, Alnemri, E. S., Piacentini, M, E S Alnemri, Zhivotovsky, B., Golstein, P., Peter, M. E., W S El-Deiry, M V Blagosklonny, Galluzzi, L, Alnemri, Emad,, Hengartner, M, D R Green, B Zhivotovsky, Yuan, J, Malorni, W., Green, DR, Kumar, S, Nuñez, G., Knight, R. A., Piacentini, M., G Nuñez +67 morecore +1 more source
