Results 151 to 160 of about 8,637,589 (310)
Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more sourceApoptotic cell death in disease : current understanding of the NCCD 2023
, 2023 Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this ...Kelly, Gemma L, Ghosh, Sourav, Vucic, Domagoj, Mastroberardino, Pier G, Altucci, Lucia, Elrod, John W, Galassi, Claudia, Garrido, Carmen, Lipton, Stuart A, Murphy, Daniel J, Verkhratsky, Alexei, Rodrigues, Cecilia M P, Novelli, Flavia, Broz, Petr, Szabadkai, Gyorgy, Villunger, Andreas, Green, Douglas R, Lemasters, John J, Conrad, Marcus, Sawa, Akira, Wang, Ruoning, Arama, Eli, Krysko, DmitriGE380020007704968010016119740000-0002-9692-2047F6642C16-F0ED-11E1-A9DE-61C894A0A6B4, Amelio, Ivano, Bove, Pierluigi, Del Sal, Giannino, Bortner, Carl D, Dawson, Ted M, Kepp, Oliver, Tang, Daolin, De Strooper, Bart, Damgaard, Rune Busk, Hengartner, Michael O, Kashkar, Hamid, Linkermann, Andreas, Mehlen, Patrick, Wood, Will, Zhou, Wenzhao, Ciliberto, Gennaro, MacFarlane, Marion, Penninger, Josef M, Guilbaud, Emma, Sun, Liming, Niklison-Chirou, Maria Victoria, Scorrano, Luca, Rajalingam, Krishnaraj, Robinson, Nirmal, Garg, Abhishek D, Mantovani, Roberto, Bartek, Jiri, Chen, Guo-Qiang, Oberst, Andrew, Barlev, Nickolai A, Becker, Christoph, Vander Heiden, Matthew G, Rudel, Thomas, Melino, Gerry, Marine, Jean-Christophe, Vanden Berghe, TomWE14001995143688801001388167F5D9F9A6-F0ED-11E1-A9DE-61C894A0A6B4, Tait, Stephen W G, Jost, Philipp J, Kaufmann, Thomas, Chen, Youhai H, Alnemri, Emad S, Hajnoczky, Gyorgy, Strapazzon, Flavie, Rizzuto, Rosario, Chen, Quan, Vanderluit, Jacqueline L, Joseph, Bertrand, Medema, Jan Paul, Tavernarakis, Nektarios, Cecconi, Francesco, Inoue, Satoshi, Stockwell, Brent R, Troy, Carol M, Sun, Qiang, Garcia-Saez, Ana J, Miao, Edward A, Ofengeim, Dimitry, Ciechanover, Aaron, Melino, Sonia, Agostinis, Patrizia, Peter, Marcus E, Madeo, Frank, Galluzzi, Lorenzo, Sun, Erwei, Puthalakath, Hamsa, Janic, Ana, Campanella, Michelangelo, Wallach, David, Martinou, Jean-Claude, Ricci, Jean-Ehrland, Lavandero, Sergio, Deberardinis, Ralph J, Malorni, Walter, Rubinsztein, David C, Zhivotovsky, Boris, Oren, Moshe, Urbano, Nicoletta, Simon, Hans-Uwe, Yamazaki, Takahiro, Turk, Boris, Manic, Gwenola, Vuri, Daniela, Rufini, Alessandro, Aqeilan, Rami I, Debatin, Klaus-Michael, Opferman, Joseph T, Munoz-Pinedo, Cristina, Piacentini, Mauro, Adam, Dieter, Wang, Ying, von Karstedt, Silvia, Zhang, Haibing, Carbone, Michele, Pagano, Michele, Hildeman, David A, Daugaard, Mads, De Maria, Ruggero, Lockshin, Richard A, He, Sudan, Schroder, Kate, Pasparakis, Manolis, Yang, Huang-Tian, Hacker, Georg, Nunez, Gabriel, Blomgren, Klas, Boya, Patricia, Zawacka-Pankau, Joanna E, Andrews, David W, Sesti, Federico, Vitale, Ilio, Hardwick, J Marie, Zhang, Lin, Sayan, Emre, Zakeri, Zahra, Klionsky, Daniel J, Bano, Daniele, Diederich, Marc, Bernassola, Francesca, Silke, John, Fimia, Gian Maria, Strasser, Andreas, Vousden, Karen H, Karin, Michael, Bianchi, Marco E, Liccardi, Gianmaria, Ganini, Carlo, Engeland, Kurt, Panaretakis, Theocharis, Calin, George A, Kumar, Sharad, Ravichandran, Kodi S, Pereira, David M, Prehn, Jochen H M, Kroemer, Guido, Marchi, Saverio, Rotblat, Barak, D'Angiolella, Vincenzo, Hetz, Claudio, Dynlacht, Brian D, Voss, Anne K, Blander, J Magarian, Aaronson, Stuart A, Bazan, Nicolas G, Chipuk, Jerry E, Kulms, Dagmar, Jaattela, Marja, El-Deiry, Wafik S, Lavrik, Inna N, Cubillos-Ruiz, Juan R, Czabotar, Peter E, Luedde, Tom, Blagosklonny, Mikhail V, Chan, Francis K-M, Dawson, Valina L, Pinton, Paolo, Porta, Giovanni, Haupt, Ygal, Brunner, Thomas, Kitsis, Richard N, Ryan, Kevin M, Sistigu, Antonella, Baehrecke, Eric H, Cheng, Emily H, Dixon, Scott J, Kluck, Ruth, Carmona-Gutierrez, Didac, Ichijo, Hidenori, Pentimalli, Francesca, Balachandran, Siddharth, Bertrand, MathieuWE140001614180038020005477810000-0001-9000-062601661B60-F0EE-11E1-A9DE-61C894A0A6B4, Kimchi, Adi, Pervaiz, Shazib, Kanneganti, Thirumala-Devi, Greene, Lloyd A, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, Degterev, Alexei, Stephanou, Anastasis, Sica, Giuseppe S, Lopez-Otin, Carlos, Moll, Ute M, Abrams, John M, Wagner, Erwin F, Blandino, Giovanni, Brenner, Catherine, Martin, Seamus J, Gronemeyer, Hinrich, Gavathiotis, Evripidis, Heery, David M, Rothlin, Carla V, Rehm, Markus, Sarosiek, Kristopher A, Shao, Feng, Meier, Pascal, Borner, Christoph, Candi, Eleonora, Walczak, Henning, Cidlowski, John A, Deshmukh, Mohanish, Pietrocola, Federico, Rabinovich, Gabriel A, Di Virgilio, Francesco, Gerlic, Motti, Agostini, Massimiliano, Shi, Yufang, Weber, Achim +227 morecore Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD) Sejung Lee, Junghyeok Lim, Jinhyuk Bhinwiley +1 more sourceCEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth +3 morewiley +1 more sourcePharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller +16 morewiley +1 more sourcePANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang +4 morewiley +1 more source
