Results 151 to 160 of about 17,178,165 (354)

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

open access: yesHepatology Communications, 2018
Fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD).
Carmen García‐Ruiz   +1 more
doaj   +1 more source

Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo

open access: yesNeurobiology of Disease, 2003
We have investigated the role of caspase-8 and its mode of activation during apoptosis of adult rat retinal ganglion cells (RGCs) in vivo. Retinal pro-caspase-8 expression was almost completely restricted to RGCs.
J.H Weishaupt   +5 more
doaj   +1 more source

Geometry shapes evolution of early multicellularity

open access: yes, 2014
Organisms have increased in complexity through a series of major evolutionary transitions, in which formerly autonomous entities become parts of a novel higher-level entity.
Kerr, Ben   +3 more
core   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

S-Adenosyl-L-Methionine protects the probiotic yest, \u3cem\u3eSaccharomyces boulardii\u3c/em\u3e, from acid-induced cell death [PDF]

open access: yes, 2013
Background Saccharomyces boulardii is a probiotic yeast routinely used to prevent and to treat gastrointestinal disorders, including the antibiotic-associated diarrhea caused by Clostridium difficile infections.
Austriaco, Nicanor   +4 more
core   +1 more source

NLRP3 inflammasome activation and cell death

open access: yesCellular & Molecular Immunology, 2021
Yi Huang, Wenjing Xu, Rongbin Zhou
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding

open access: yesSignal Transduction and Targeted Therapy, 2021
Zubiao Niu   +9 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Cell fusion in the pathogenesis of COVID-19

open access: yesMilitary Medical Research, 2021
You Zheng   +3 more
doaj   +1 more source

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