Results 71 to 80 of about 3,312,655 (209)

Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion

Cells, 2020
Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients.
Ditte Marie Brix, Knut Kristoffer Bundgaard Clemmensen, Tuula Kallunki   +2 more
doaj   +1 more source

Targeting oxeiptosis-mediated tumor suppression: a novel approach to treat colorectal cancers by sanguinarine

Cell Death Discovery, 2023
Oxeiptosis is a recently identified reactive oxygen species (ROS)-sensitive, caspase independent, non-inflammatory regulated cell death pathway. The activation of Kelch-like ECH-associated protein 1-Phosphoglycerate mutase 5-Apoptosis inducing factor ...
Siraj Pallichankandy, Faisal Thayyullathil, Anees Rahman Cheratta, Karthikeyan Subburayan, Ameer Alakkal, Mehar Sultana, Nizar Drou, Muhammad Arshad, Saeed Tariq, Sehamuddin Galadari   +9 more
doaj   +1 more source

An annotated high-content fluorescence microscopy dataset with Hoechst 33342-stained nuclei and manually labelled outlines

Data in Brief, 2023
Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as ...
Malou Arvidsson, Salma Kazemi Rashed, Sonja Aits   +2 more
doaj   +1 more source

Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity

Livers
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (MPT).
Jiangting Hu, Anna-Liisa Nieminen, Zhi Zhong, John J. Lemasters   +3 more
doaj   +1 more source

Recent advances in understanding inhibitor of apoptosis proteins [version 1; referees: 2 approved]

F1000Research, 2018
The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity.
Najoua Lalaoui, David Lawrence Vaux
doaj   +1 more source

Cell Stress and Cell Death

International Journal of Cell Biology, 2010
This special issue on Cell Stress and Cell Death is aimed at bringing together recent developments in the fields of cellular stress and cell death and, in particular, the interplay between cell stress responses and cell death. The special issue opens with a review by S. Fulda et al.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, Srinivasa M. Srinivasula   +4 more
openaire   +5 more sources

Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]

, 2017
Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet, Bayir, Hulya, Liu, Bing, Oltvai, Zoltan N, Pak, Stephen C, Perlmutter, David H, Silverman, Gary A   +6 more
core   +3 more sources

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]

, 2013
Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda, Bodur, Çağrı, Harrison, Paul, Isimjan, Tayirjan T., Karslı, Gizem, Kütük, Özgür   +5 more
core   +1 more source

BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis

Autophagy Reports
Epithelial and endothelial barriers are essential for tissue homeostasis, protecting the body from environmental insults while regulating selective transport. The integrity of these barriers relies on dynamic intercellular junctions whose composition and
Juliani Juliani, Walter D. Fairlie, Erinna F. Lee   +2 more
doaj   +1 more source

Cell death throes

Proceedings of the National Academy of Sciences, 1998
Living cells come equipped with a highly efficient death machinery that is readily activated when they reach their duly allotted life span or are deemed to be ineffectual, redundant, or damaged. The existence of a genetic death program was first inferred from the ordered morphologic changes revealed by electron micrographs of dying cells from organisms
openaire   +3 more sources