Results 111 to 120 of about 2,690,374 (356)

Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division

Cell Reports
Summary: Cell division is tightly regulated and requires an expanded energy supply. However, how this energy is generated remains unclear. Here, we establish a correlation between two mitochondrial Ca2+ influx events and ATP production during mitosis ...
Gan Zhao, Mingkang Jia, Shicong Zhu, He Ren, Guopeng Wang, Guangwei Xin, Mengjie Sun, Xiangyang Wang, Qiaoyu Lin, Qing Jiang, Chuanmao Zhang   +10 more
doaj   +1 more source

Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks [PDF]

, 2011
Sören Abel, Peter Chien, Paul Wassmann, Tilman Schirmer, Volkhard Kaever, Michael T. Laub, Tania A. Baker, Urs Jenal   +7 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

iCAT as an open-source platform for axial rotation and high-resolution imaging of organoids and living organisms

Communications Biology
In dynamic light microscopy applications, imaging specimens from multiple angles while maintaining controlled temperature conditions is crucial for comprehensive and accurate analysis.
Ondřej Svoboda, Olga Machoňová, Petr Bartůněk   +2 more
doaj   +1 more source

Phylogenetic Analysis of Cell Types using Histone Modifications

, 2013
In cell differentiation, a cell of a less specialized type becomes one of a more specialized type, even though all cells have the same genome. Transcription factors and epigenetic marks like histone modifications can play a significant role in the ...
Bucher, Philipp, Lin, Yu, Moret, Bernard M. E., Nair, Nishanth Ulhas   +3 more
core   +1 more source

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells [PDF]

, 2013
Andrei N. Mardaryev, Michał R. Gdula, Joanne L. Yarker, Vladimir U. Emelianov, Krzysztof Poterlowicz, Andrey A. Sharov, Tatyana Sharova, Julie A. Scarpa, Pierre Chambon, Vladimir A. Botchkarev, Michael Y. Fessing   +10 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

COMMITMENT DURING NEMATOCYTE DIFFERENTIATION IN HYDRA [PDF]

, 1981
Nematocytes in Hydra differentiate from interstitial stem cells. Desmonemes differentiate mainly in the distal half of the body column while stenoteles differentiate predominantly in the proximal half.
David, Charles N., Fujisawa, Toshitaka
core  

Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells [PDF]

, 2022
Shuhei Tanemura, Noriyasu Seki, Hideto Tsujimoto, Shuntaro Saito, Jun Kikuchi, Kunio Sugahara, Keiko Yoshimoto, Katsuya Suzuki, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi   +10 more
openalex   +1 more source