Results 151 to 160 of about 1,598,992 (308)

Graphene Oxide Laser Printing for Controlled STEM Cells Differentiation and Antibacterial Effects [PDF]

, 2018
Valentina Palmieri, Marta Barba, Lorena Di Pietro, Silvia Gentilini, Francesca Bugli, R. Larciprete, Wanda Lattanzi, Maurizio Sanguinetti, Marco De Spirito, C. De Conti, Massimiliano Papi   +10 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PAI-1: A Key Signal at the Crossroads of Stem Cell Differentiation and Senescence. [PDF]

Int J Mol Sci
Ke J, Jiang Y, Cheng Z, Zhou Y, Lu J, Xu B, Yan S, Wang J.   +7 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

DIS3 licenses B cells for plasma cell differentiation in humans. [PDF]

Cell Mol Immunol
Miglierina E, Bouder J, Ordanoska D, Pineau M, Léonard S, Schavgoulidze A, Quéré G, Le Goff M, Bouchet M, Genebrier SA, Trinca SBS, Deleurme L, Monvoisin C, Derrier L, Dumontet C, Delpy L, Moreaux J, Corre J, Cogné M, Laffleur B.   +19 more
europepmc   +1 more source

A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis

Maria Eischen‐Loges, Zeinab Tahmasebi Birgani, Yousra Alaoui Selsouli, Lars Eijssen, Hoon Suk Rho, Mireille M.J.P.E. Sthijns, Martijn van Griensven, Vanessa L.S. LaPointe, Pamela Habibović   +8 more
openalex   +1 more source

Additional file 6 of Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium

, 2023
Zhi Dong, Lan Pang, Zhiguo Liu, Yifeng Sheng, Xiaoping Li, Xavier Thibault, Amy Reilein, Daniel Kalderon, Jianhua Huang   +8 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation. [PDF]

Front Immunol
Tieppo P, Shehade H, Martinoli C, Mercier M, Carbonez D, Rosewick N, Jung S, Vezzu A, Pirlot B, Wald N, Ma S, Chaible L, Marillier R, Strozzi F, Dieu-Nosjean MC, Marchante J, Brouwer M, Houthuys E, Deligny M, McGrath Y, Rossetti M.   +20 more
europepmc   +1 more source

Additional file 3 of LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4

, 2022
Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He, Yongxiang Wang   +7 more
openalex   +1 more source