Results 161 to 170 of about 1,598,992 (308)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Key regulatory roles of PRDM1 in human NK-cell differentiation and activation. [PDF]

Leukemia
Liu X, Shi Y, Zhang J, Shetty K, Chew K, Küçük C, Gong Q, Esmeray E, Li H, Chen R, Pan S, Dąbrowska K, Moore RE, Garcia-Mansfield K, Pirrotte P, Wang J, Li Y, Dong G, Lee L, McKeithan TW, Iqbal J, Chan WC.   +21 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Bone Morphogenetic Protein 6 Attenuates Psoriasis Pathogenesis by Suppressing Th17 Cell Differentiation. [PDF]

Inflammation
Fu J, Chen Y, Zhao R, Wu B, Du J, Xu J, Liu Y.   +6 more
europepmc   +1 more source

Dysregulation of the CD4 + T cells lineage differentiation in dyslipidemic patients and impact of lipoprotein-apheresis treatment: A case study

, 2017
J. Papin, Ana Brennand, Giuseppina Arbore, Bernd Hohenstein, Virginia Kamvissi, Claudia Kemper, Stefan R. Bornstein   +6 more
openalex   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. [PDF]

J Exp Med
Xu L, Bottermann M, Villavicencio PM, Warner J, Weldon SR, Xie Z, Filby A, Liu X, Ganley IG, Ringel AE, Nair U, Batista FD.   +11 more
europepmc   +1 more source

Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing [PDF]

Yueh-An Lu, Tanya Smith, Sumukh Deshpande, Chia‐Te Liao, Bnar Talabani, I. V. Grigorieva, Anna Mason, Robert Andrews, Timothy Bowen, Philip R. Taylor, Donald Fraser   +10 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function. [PDF]

Sci Adv
Xie L, Zhang R, Zou H, Hu J, Deng J, Ding J, Liu L, Lin Q, Zhao B, Xu A, Zhou Z, Xiao Y.   +11 more
europepmc   +1 more source