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Osteoblastic cells: Differentiation and trans-differentiation
Archives of Biochemistry and Biophysics, 2008The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that ...
Kassem, Moustapha +2 more
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Erythroid Cell Differentiation
1976We have reviewed erythroid cell differentiation from two points of view: 1) differences between fetal and adult human red cells with particular reference to alterations which can occur in the normal pattern of erythroid cell development during the course of leukemia; 2) beochemical events which occur during erythroid cell maturation, as a model system ...
B G, Forget, J, Glass, D, Housman
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Cartilage Cell Differentiation
Clinical Orthopaedics and Related Research, 1979Differentiation of cartilage cells from embryonic precursor cells is characterized by the onset of biosynthesis of at least two cartilage-specific gene products, type II collagen and cartilage-specific chondroitin sulfate proteoglycan (CSPG). Biochemical and immunological assays for these compounds now allow rapid, quantitative, and specific ...
K, von der Mark, G, Conrad
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Current Opinion in Cell Biology, 1989
The appeal of myogenic differentiation as a model developmental system derives in part from the complexity of regulatory steps required to account for the diversity of muscle structure and function. The intricate patterns of contractile tissue formation in the adult animal depend on the orderly progression of molecular signals that lead primordial ...
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The appeal of myogenic differentiation as a model developmental system derives in part from the complexity of regulatory steps required to account for the diversity of muscle structure and function. The intricate patterns of contractile tissue formation in the adult animal depend on the orderly progression of molecular signals that lead primordial ...
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Science, 2017
Innate Immunity Hematopoietic stem cells are a common progenitor of adaptive and innate immune cells. However, the precise factors that guide differentiation down these disparate pathways remain unclear, in part owing to difficulties in working with small numbers of precursor cells. Lee et al .
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Innate Immunity Hematopoietic stem cells are a common progenitor of adaptive and innate immune cells. However, the precise factors that guide differentiation down these disparate pathways remain unclear, in part owing to difficulties in working with small numbers of precursor cells. Lee et al .
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1987
All lymphocytes are derived from an unidentified multipotent precursor (Fig. 10.1). T cell precursors migrate from the liver and bone marrow in fetal life and from the bone marrow in adult life, to the thymus. It is unknown whether the stem cells become committed to T cell differentiation before or after they have entered the thymus.
Ian J. Forbes, Anthony S-Y. Leong
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All lymphocytes are derived from an unidentified multipotent precursor (Fig. 10.1). T cell precursors migrate from the liver and bone marrow in fetal life and from the bone marrow in adult life, to the thymus. It is unknown whether the stem cells become committed to T cell differentiation before or after they have entered the thymus.
Ian J. Forbes, Anthony S-Y. Leong
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Cell Differentiation and Malignancy
Cell Biophysics, 1986An understanding of the mechanism that controls growth and differentiation in normal cells would seem to be an essential requirement to elucidate the origin and reversibility of malignancy. For this approach I have mainly used normal and leukemic blood cells, and in most studies have used myeloid blood cells as a model system.
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