Results 31 to 40 of about 12,907,435 (362)

Differentiation of effector CD4 T cell populations (*).

Annual Review of Immunology, 2010
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity.
Jinfang Zhu, H. Yamane, W. Paul
semanticscholar   +1 more source

The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration

Stem Cell Research & Therapy, 2023
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication.
Mei Yang, Guang-hua Peng
doaj   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

Science, 2018
Mapping Hydra development cell by cell Hydra continually renews all cells in its body using three stem cell populations. This feature of Hydra allowed Siebert et al.
S. Siebert, J. A. Farrell, Jack F. Cazet, Yashodara Abeykoon, Abby S. Primack, C. Schnitzler, Celina E. Juliano   +6 more
semanticscholar   +1 more source

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Nature Communications, 2018
Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao   +10 more
doaj   +1 more source

Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

eLife, 2016
Dynamic remodeling of the intrahepatic biliary epithelial tissue plays key roles in liver regeneration, yet the cellular basis for this process remains unclear.
Kenji Kamimoto, Kota Kaneko, Cindy Yuet-Yin Kok, Hajime Okada, Atsushi Miyajima, Tohru Itoh   +5 more
doaj   +1 more source

Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells

Scientific Reports, 2021
Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia.
Naoko Katagiri, Hirofumi Hitomi, Shin-Ichi Mae, Maki Kotaka, Li Lei, Takuya Yamamoto, Akira Nishiyama, Kenji Osafune   +7 more
doaj   +1 more source

Therapeutic targets for metabolic dysfunction-associated steatotic liver disease and their roles in hepatocellular carcinoma

Exploration of Digestive Diseases, 2023
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common chronic liver diseases. Over time, there has been a significant increase in the prevalence of MASLD.
Chenyu Wei, Jianing Wu, Chaoyang Zhang, Yinshen Zhao, Chunzheng Li, Xianguang Yang   +5 more
doaj   +1 more source

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs

Nature Communications, 2018
The genomic loci associated with B cell differentiation that are subject to transcriptional and epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the development of humoral immune responses.
Christopher D. Scharer, B. Barwick, M. Guo, Alexander P R Bally, J. Boss   +4 more
semanticscholar   +1 more source

Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation

FEBS Open Bio, 2020
Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé, Amel Bouchatal, Frédéric Chirat, Yann Guérardel, Abderrahman Maftah, Jean‐Michel Petit   +5 more
doaj   +1 more source