Results 31 to 40 of about 11,748,111 (318)
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Nature Communications, 2017 Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response ...
Masahide Kawatou +6 more
doaj +1 more source
The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse
Scientific Reports, 2018 The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start ...
Valérie Bégay +4 more
doaj +1 more source
Differentiation of effector CD4 T cell populations (*).
Annual Review of Immunology, 2010 CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity.
Jinfang Zhu, H. Yamane, W. Paul
semanticscholar +1 more source
Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel
Nature, 2018 Somatic stem cells constantly adjust their self-renewal and lineage commitment by integrating various environmental cues to maintain tissue homeostasis.
Li He +4 more
semanticscholar +1 more source
Revolutionizing Single Cell Analysis: The Power of Large Language Models for Cell Type Annotation [PDF]
arXiv, 2023 In recent years, single cell RNA sequencing has become a widely used technique to study cellular diversity and function. However, accurately annotating cell types from single cell data has been a challenging task, as it requires extensive knowledge of cell biology and gene function. The emergence of large language models such as ChatGPT and New Bing in
arxiv
Non-genetic heterogeneity criticality and cell differentiation [PDF]
Phys.Biol.12(2015)016001, 2014 The different cell types in a living organism acquire their identity through the process of cell differentiation in which the multipotent progenitor cells differentiate into distinct cell types. Experimental evidence and analysis of large-scale microarray data establish the key role played by a two-gene motif in cell differentiation in a number of cell
arxiv +1 more source
Journal of Cellular Physiology, 2017 The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes.
Tong Chen +3 more
semanticscholar +1 more source
Nature Communications, 2018 Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu +10 more
doaj +1 more source
Stem Cell Research & Therapy, 2023 Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication.
Mei Yang, Guang-hua Peng
doaj +1 more source
Mathematical modeling of heterogeneous stem cell regeneration: from cell division to Waddington's epigenetic landscape [PDF]
arXiv, 2023 Stem cell regeneration is a crucial biological process for most self-renewing tissues during the development and maintenance of tissue homeostasis. In developing the mathematical models of stem cell regeneration and tissue development, cell division is the core process connecting different scale biological processes and leading to changes in cell ...
arxiv