Results 51 to 60 of about 1,464,786 (217)

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy

open access: yesInflammation and Regeneration
In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or genetically modified T cells engineered ...
Sota Kurihara   +2 more
doaj   +1 more source

Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division

open access: yesCell Reports
Summary: Cell division is tightly regulated and requires an expanded energy supply. However, how this energy is generated remains unclear. Here, we establish a correlation between two mitochondrial Ca2+ influx events and ATP production during mitosis ...
Gan Zhao   +10 more
doaj   +1 more source

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

open access: yesNature Communications, 2017
Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu   +9 more
doaj   +1 more source

Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis

open access: yesGenome Biology, 2018
Background Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this process at single-cell resolution ...
Ji Dong   +8 more
doaj   +1 more source

Transplantation of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Reveals a Site-Specific Survival, Growth, and Differentiation

open access: yesCell Transplantation, 2013
Development of β-cells from human embryonic stem cells (hESCs) could compensate for the shortage of islet donors required for diabetes therapy. Although pancreatic progenitors have been derived from hESCs using various protocols, no fully functional β ...
Lina Sui   +4 more
doaj   +1 more source

T cell differentiation [PDF]

open access: yesThe International Journal of Cell Cloning, 1986
openaire   +3 more sources

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