Results 1 to 10 of about 1,174,140 (120)
Principles of dormancy evident in high-grade serous ovarian cancer
Cell Division, 2022 In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy.
Trevor G. Shepherd, Frederick A. Dick
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Emerging roles of the SUMO pathway in mitosis
Cell Division, 2008 SUMO proteins are small ubiquitin-like modifiers found in all eukaryotes that become covalently conjugated to other cellular proteins. The SUMO conjugation pathway is biochemically similar to ubiquitin conjugation, although the enzymes within the pathway
Dasso Mary
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Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
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The many faces of ubiquitinated histone H2A: insights from the DUBs
Cell Division, 2008 Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the context of chromatin is a challenging question.
Di Fiore Pier +4 more
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Cell Division, 2018 Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions.
Steven Boeynaems +2 more
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"ATR activation in response to ionizing radiation: still ATM territory"
Cell Division, 2006 Unrepaired DNA double-strand breaks (DSBs) are a major cause for genomic instability. Therefore, upon detection of a DSB a rapid response must be assembled to coordinate the proper repair/signaling of the lesion or the elimination of cells with ...
Cuadrado Myriam +2 more
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MicroRNAs’ control of cancer cell dormancy
Cell Division, 2019 ‘Dormancy’, in the context of carcinogenesis, is a biological phenomenon of decreased cancer cell proliferation and metabolism. In view of their ability to remain quiescent, cancer cells are able to avoid cell death induced by chemotherapeutic agents ...
Tatiana G. Ruksha
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"Cullin 4 makes its mark on chromatin"
Cell Division, 2006 Cullin 4 (Cul4), a member of the evolutionally conserved cullin protein family, serves as a scaffold to assemble multisubunit ubiquitin E3 ligase complexes.
Wang Hengbin, Dai Qian
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Cell Division, 2011 Eukaryotic chromatin is a combination of DNA and histone proteins. It is established fact that epigenetic mechanisms are associated with DNA and histones.
Nazar Shazia +5 more
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Polo-like kinase 4: the odd one out of the family
Cell Division, 2010 Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
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