Results 91 to 100 of about 7,478,668 (259)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions [PDF]

, 2006
Background: The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development.
Slack Cathy, W Somers, Sousa-Nunes, Rita, Chia, W., Chia William, Cathy Slack, Chia, W, Slack, C, Somers W, Sousa-Nunes, R., Somers, W. Gregory, Paul M Overton, Somers, W G, Slack, Cathy, Overton Paul M, Rita Sousa-Nunes, Overton, P M, William Chia, Sousa-Nunes Rita, Slack, C., Overton, Paul M., Somers, W.G., Overton, P.M., Chia, William, Sousa-Nunes, Rita; id_orcid   +24 more
core   +1 more source

The nature of cell division forces in epithelial monolayers

, 2021
Epithelial cells undergo striking morphological changes during division to ensure proper segregation of genetic and cytoplasmic materials. These morphological changes occur despite dividing cells being mechanically restricted by neighboring cells ...
Ovijit Chaudhuri, Chaudhuri, Ovijit, Vivek K. Gupta, Lucy Erin O’Brien, Camuglia, Jaclyn, Nam, Sungmin, Sanders, Erin Nicole, Donghyun Yim, Kim, Taeyoon, Adam C. Martin, O’Brien, Lucy Erin, Erin Nicole Sanders, Martin, Adam C, Yim, Donghyun, Sungmin Nam, Judy Lisette Martin, Jaclyn Camuglia, Martin, Judy Lisette, Taeyoon Kim, Gupta, Vivek K   +19 more
core   +1 more source

CIP/KIP and INK4 families as hostages of oncogenic signaling

Cell Division
CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their function.
Lucia Csergeová, David Krbušek, Radoslav Janoštiak   +2 more
doaj   +1 more source

The many faces of ubiquitinated histone H2A: insights from the DUBs

Cell Division, 2008
Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the context of chromatin is a challenging question.
Di Fiore Pier, van Lohuizen Maarten, Nicassio Francesco, Vissers Joseph HA, Citterio Elisabetta   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal [PDF]

, 2012
Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data.
Jonas Steinmann, Heinrich Reichert, Reichert, Heinrich, Maria Novatchkova, Burkard, Thomas R., Laurenson, Anne-Sophie, Anne-Sophie Laurenson, Knoblich, Juergen A., Steinmann, Jonas, van der Horst, Suzanne, Berger, Christian, Novatchkova, Maria, Christian Berger, Juergen A. Knoblich, Thomas R. Burkard, Heike Harzer, Suzanne van der Horst, Harzer, Heike   +17 more
core   +1 more source

Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division

, 2021
© 2020 Ko et al. During development, coordinated cell shape changes and cell divisions sculpt tissues. While these individual cell behaviors have been extensively studied, how cell shape changes and cell divisions that occur concurrently in epithelia ...
Martin, Adam C, Ko, Clint S, Kalakuntla, Prateek   +2 more
core   +1 more source