Results 101 to 110 of about 7,903,122 (310)

Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry

Cell Division, 2010
The kinase Wee1 has been recognized for a quarter century as a key inhibitor of Cyclin dependent kinase 1 (Cdk1) and mitotic entry in eukaryotes. Nonetheless, Wee1 regulation is not well understood and its large amino-terminal regulatory domain (NRD) has
Enders Greg H
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dynamic assembly, disassembly and bundling of the bacterial cell division protein FtsZ and YgfE (ZapA) [PDF]

The protein FtsZ is a tubulin-like GTPase, which plays an essential role in prokaryotic cell division. In vivo it assembles into a dynamic ring (the Z-ring) at the future site of cell division on the inner surface of the cytoplasmatic membrane.
Cheng, Xi, Ph.D.
core  

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. [PDF]

, 2017
RhoA-mediated regulation of myosin-II activity in the actin cortex controls the ability of cells to contract and bleb during a variety of cellular processes, including cell migration and division.
Valderrama, F, Ferran Valderrama, Michael Way, Yutaka Handa, Handa, Y, Way, Michael, Cordeiro, JV, Flavia Leite, Valderrama, Ferran, Way, M, Handa, Yutaka, Charlotte H. Durkin, Arakawa, Yoshiki, Durkin, CH, Cordeiro, João V, João V. Cordeiro, Leite, Flavia, Durkin, Charlotte H, Yoshiki Arakawa, Leite, F, Arakawa, Y   +20 more
core   +1 more source

Linking asymmetric cell division, CD8+ T cell fate, and signal strength

, 2023
Through live imaging of CD8+ T cells carrying a fate reporter, Gräbnitz et al. directly linked (a)symmetric division to T cell fate.1 Asymmetry during the first division ensured the generation of stem-like CD8+ T cells following strong T cell ...
Carmen Gerlach, Jyoti Pokharel, Gerlach, C,, Pokharel, J,   +3 more
core   +1 more source

The role of β-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells

Cell Division, 2013
Background Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that β-
Ji Yi, Chen Siyuan, Li Kai, Xiao Xianmin, Zheng Shan, Xu Ting   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Free SepF interferes with recruitment of late cell division proteins [PDF]

, 2017
The conserved cell division protein SepF aligns polymers of FtsZ, the key cell division protein in bacteria, during synthesis of the (Fts)Z-ring at midcell, the first stage in cytokinesis.
Wenzel, M., Jonker, M.J., Hamoen, L.W., Gao, Y., Hamoen, L.W.; id_orcid   +4 more
core   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. [PDF]

, 2016
Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear.
Lipkin, Steven M., Murthy, Preetish Kadur Lakshminarasimha, Bu, Pengcheng, Murthy, Preetish Kadur Lakshminarasimha, Varanko, Anastasia Kristine, King, Sarah, Ai, Yiwei, Chen, Kai-Yuan, Tung, Kuei-Ling, Varanko, Anastasia Kristine, Chen, Huanhuan Joyce, Wang, Lihua, Lipkin, Steven M, Shen, Xiling, Srinivasan, Tara, Chen, Huanhuan Joyce   +15 more
core   +1 more source