Results 21 to 30 of about 2,334,308 (350)
Background The SNP rs671 of Human aldehyde dehydrogenase (ALDH) is G-A transition at 1510th nucleotides, which is an important clinical indicator of alcoholic liver disease, digestive tract cancer and some drug efficiency.
Fang Wu+6 more
doaj +1 more source
Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
Haematopoietic cell number is maintained by a delicate balance between cell proliferation, differentiation and death. Gene knockout studies in mice have revealed the complex roles of cyclins, CDKs, and CDK inhibitors in regulating cell proliferation and ...
Lam Eric, Myatt Stephen S
doaj +1 more source
Morphology of Proliferating Epithelial Cellular Tissue [PDF]
We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective division and ...
Baumeier, Björn+3 more
core +2 more sources
Can eukaryotic cells monitor the presence of unreplicated DNA?
Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow time for those
Aragón Luis+2 more
doaj +1 more source
Influence of cell cycle phase on calcification in the coccolithophore Emiliania huxleyi [PDF]
Calcification of the cosmopolitan coccolithophore species Emiliania huxleyi was investigated in relation to the cell division cycle with the use of batch cultures.
Antia, Avan+2 more
core +1 more source
The role of CDK in the initiation step of DNA replication in eukaryotes
Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication.
Tak Yon-Soo+2 more
doaj +1 more source
Reconstruction of the kinetochore: a prelude to meiosis
In eukaryotic organisms, chromosomes are spatially organized within the nucleus. Such nuclear architecture provides a physical framework for the genetic activities of chromosomes, and changes its functional organization as the cell moves through the ...
Haraguchi Tokuko+2 more
doaj +1 more source
Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle
Background The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly.
Hervouet Eric+4 more
doaj +1 more source
Division in synthetic cells [PDF]
Cell division is one of the most fundamental processes of life, and so far the only known way of how living systems can come into existence at all. Consequently, its reconstitution in any artificial cell system that will have to be built from the bottom-up is a notoriously complex but an important task.
openaire +4 more sources
A software solution for recording circadian oscillator features in time-lapse live cell microscopy
Background Fluorescent and bioluminescent time-lapse microscopy approaches have been successfully used to investigate molecular mechanisms underlying the mammalian circadian oscillator at the single cell level. However, most of the available software and
Salmon Patrick+3 more
doaj +1 more source