Results 41 to 50 of about 1,174,140 (120)
How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor
Cell Division, 2007 Oocytes from higher chordates, including man and nearly all mammals, arrest at metaphase of the second meiotic division before fertilization. This arrest is due to an activity that has been termed 'Cytostatic Factor'.
Jones Keith T, Madgwick Suzanne
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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
Cell Division, 2010 Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis.
van Wely Karel HM +2 more
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Cell Division, 2010 Maintenance of genomic integrity is important for cellular viability and proliferation. During DNA replication, cells respond to replication stress by activating checkpoint pathways that stabilize replication forks and prevent cell cycle progression. The
Koepp Deanna M
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Septins: molecular partitioning and the generation of cellular asymmetry
Cell Division, 2009 During division, certain cellular contents can be distributed unequally; daughter cells with different fates have different needs. Septins are proteins that participate in the establishment and maintenance of asymmetry during cell morphogenesis, thereby ...
Thorner Jeremy, McMurray Michael A
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The function of APC/CCdh1 in cell cycle and beyond
Cell Division, 2009 The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates.
Zhang Pumin, Li Min
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GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms
Cell Division, 2010 Background c-Myb is expressed at high levels in immature progenitors of all the hematopoietic lineages. It is associated with the regulation of proliferation, differentiation and survival of erythroid, myeloid and lymphoid cells, but decreases during the
Suzuki Sayuri +7 more
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Measuring DNA content in live cells by fluorescence microscopy
Cell Division, 2018 Background Live-cell fluorescence microscopy (LCFM) is a powerful tool used to investigate cellular dynamics in real time. However, the capacity to simultaneously measure DNA content in cells being tracked over time remains challenged by dye-associated ...
Cecil J. Gomes +4 more
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APC/C – the master controller of origin licensing?
Cell Division, 2007 DNA replication must be tightly controlled to prevent initiation of a second round of replication until mitosis is complete. So far, components of the pre-replicative complex (Cdt1, Cdc6 and geminin) were considered key players in this regulation.
Dutta Anindya +2 more
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CIP/KIP and INK4 families as hostages of oncogenic signaling
Cell DivisionCIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their function.
Lucia Csergeová +2 more
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Cell DivisionBackground Nuclear-enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), has been implicated in the colorectal cancer (CRC) progression. However, its upstream mechanism has not been well studied.
Anlong Ji +4 more
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