Results 51 to 60 of about 7,478,668 (259)

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]

, 2013
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep, Munshi, T, Sanjib Bhakta (106475), Bhakta, S, Gupta, A, Gibbons, S., Simon Gibbons (391868), Nicholas H. Keep (392673), Antima Gupta, Keep, Nicholas H., Gibbons, Simon, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Juan David Guzman (392672), Gibbons, S, Simon Gibbons, Dimitrios Evangelopoulos (392671), Tulika Munshi (392669), Antima Gupta (392670), Juan David Guzman, Evangelopoulos, D, Guzman, Juan David, Gupta, Antima, Dimitrios Evangelopoulos, Munshi, Tulika, Sanjib Bhakta, Keep, NH, Guzman, Juan D., Guzman, JD, Tulika Munshi   +29 more
core   +1 more source

Emerging players in the initiation of eukaryotic DNA replication

Cell Division, 2012
Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre-IC) at the beginning of DNA replication ...
Shen Zhen, Prasanth Supriya G
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Identification of transcriptional and metabolic programs related to mammalian cell size [PDF]

, 2014
Background Regulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and ...
Mlettinen, Teemu P., Pessa, Heli K. J., Bjoerklund, Mikael, Diril, M. Kasim, Pessa, Heli K.J., Sauer, Uwe; id_orcid, Fuhrer, Tobias, Kaldis, Philipp, Sauer, Uwe, Bjorklund, Mikael, DİRİL, MUHAMMED KASIM, Caldez, Matias J., Miettinen, Teemu P.   +12 more
core   +1 more source

Transient defects of mitotic spindle geometry and chromosome segregation errors

Cell Division, 2012
Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome segregation and prevent aneuploidy, and severe mitotic spindle defects are typically associated with cell death. Recent studies have shown that mitotic spindles with initial
Silkworth William T, Cimini Daniela
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

"ATR activation in response to ionizing radiation: still ATM territory"

Cell Division, 2006
Unrepaired DNA double-strand breaks (DSBs) are a major cause for genomic instability. Therefore, upon detection of a DSB a rapid response must be assembled to coordinate the proper repair/signaling of the lesion or the elimination of cells with ...
Cuadrado Myriam, Martinez-Pastor Barbara, Fernandez-Capetillo Oscar   +2 more
doaj   +1 more source

Development and validation of a two glycolysis-related LncRNAs prognostic signature for glioma and in vitro analyses

Cell Division, 2023
Background Mounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic process during glioma development.
Xiaoping Xu, Shijun Zhou, Yuchuan Tao, Zhenglan Zhong, Yongxiang Shao, Yong Yi   +5 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Fueling the cell division cycle

, 2017
Salazar-Roa, Maria as first author. M.S.R. thanks the Asociación Española contra el Cáncer (AECC) for support. Research in the laboratory of the authors is supported by grants from the Comunidad de Madrid (S2010/BMD-2470), Spanish Ministry of Economy and
Malumbres, Marcos, Salazar Roa, María
core   +1 more source