Results 31 to 40 of about 5,474,086 (199)

Rethinking cell growth models [PDF]

FEMS Yeast Research, 2016
The minimal description of a growing cell consists of self-replicating ribosomes translating the cellular proteome. While neglecting all other cellular components, this model provides key insights into the control and limitations of growth rate. It shows, for example, that growth rate is maximized when ribosomes work at full capacity, explains the ...
Moshe, Kafri, Eyal, Metzl-Raz, Felix, Jonas, Naama, Barkai   +3 more
openaire   +2 more sources

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny

Regenerative Therapy
Introduction: Allogeneic iPSCs provide a potential source for regenerative T cell therapies, yet their clinical application remains limited by immune rejection driven by human leukocyte antigen (HLA) incompatibility.
Jing Zhang, Keisuke Sumide, Keitaro Kanie, Akihiro Ishikawa, Munehiro Yoshida, Tomoko Ishii, Bo Wang, Shin Kaneko   +7 more
doaj   +1 more source

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

Orphanet Journal of Rare Diseases, 2022
Background Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification (HO) in soft tissues due to a heterozygous mutation of the ACVR1A gene (FOP-ACVR1A), which erroneously transduces the ...
Hirotsugu Maekawa, Yonghui Jin, Megumi Nishio, Shunsuke Kawai, Sanae Nagata, Takeshi Kamakura, Hiroyuki Yoshitomi, Akira Niwa, Megumu K. Saito, Shuichi Matsuda, Junya Toguchida   +10 more
doaj   +1 more source

Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [PDF]

, 2015
The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment.
Daniela A. Ferraro, Dexter, Gerhard Christofori, Jourdan, Karey, Lamm, Marco Archetti   +6 more
core   +1 more source

Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system

Regenerative Therapy
Introduction: Genetically modified human induced pluripotent stem cell (iPSC)-based regenerative medicine has substantial potential in the treatment of refractory human diseases.
Masahiro Tanaka, Yoshihiro Iwamoto, Bo Wang, Eri Imai, Munehiro Yoshida, Shoichi Iriguchi, Shin Kaneko   +6 more
doaj   +1 more source

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control

Inflammation and Regeneration
Background Induced pluripotent stem cell (iPSC)–derived T cells offer a renewable source for off-the-shelf immunotherapy. With the advent of the artificial thymic organoid (ATO) method, the in vitro differentiation of CD4+ T cells from iPSCs has also ...
Qingyi Guo, Chaoqi Zhang, Bo Wang, Shoichi Iriguchi, Akihiro Ishikawa, Atsutaka Minagawa, Tomoko Ishii, Yohei Kawai, Shin Kaneko   +8 more
doaj   +1 more source

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Nature Communications, 2016
Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte ...
Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki   +14 more
doaj   +1 more source

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Stem Cell Reports, 2017
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu, Mio Iwasaki, Hitomi Takakubo, Takumi Sakamoto, Takeshi Ikuno, Mami Miyoshi, Takayuki Kondo, Yoichi Nakao, Masato Nakagawa, Haruhisa Inoue, Jun K. Yamashita   +10 more
doaj   +1 more source

The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline

Frontiers in Cell and Developmental Biology, 2020
Diabetes significantly induces cognitive dysfunction. Neuronal apoptosis is the main cause of diabetes-induced cognitive decline (DICD). Apoptosis signal-regulating kinase 1 (ASK1) and endoplasmic reticulum (ER) stress are remarkably activated by ...
Yanqing Wu, Yanqing Wu, Yuan Yuan, Chengbiao Wu, Ting Jiang, Beini Wang, Jun Xiong, Peipei Zheng, Yiyang Li, Jingyu Xu, Ke Xu, Yaqian Liu, Xiaokun Li, Jian Xiao   +13 more
doaj   +1 more source