Results 81 to 90 of about 5,474,086 (199)

Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin

Regenerative Therapy
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of CD19-positive B-cell malignancies. However, the field is rapidly evolving to target other antigens, such as podocalyxin (PODXL), a transmembrane protein implicated in ...
Yuta Mishima, Shintaro Okada, Akihiro Ishikawa, Bo Wang, Masazumi Waseda, Mika K. Kaneko, Yukinari Kato, Shin Kaneko   +7 more
doaj   +1 more source

CSMA: A Standalone and ImageJ-Compatible Tool for Enhanced Wound Healing Assay Analysis

IEEE Access
Accurate quantification of wound closure in cell migration assays is crucial yet challenging. Still, existing methods often underperform due to omitting cell detection within the wound area, resulting in biased outcomes.
Tri Thanh Pham, Amina Sagymbayeva, Timur Elebessov, Zhadyra Onzhanova, Ferdinand Molnar   +4 more
doaj   +1 more source

Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid

Nature Communications
Anti-pituitary-specific transcription factor (PIT)−1 hypophysitis is an autoimmune disease characterized by hormone secretion impairment from PIT-1-expressing pituitary cells, accompanied by malignancies with ectopic PIT-1 expression.
Keitaro Kanie, Takeshi Ito, Genzo Iguchi, Ryusaku Matsumoto, Keiko Muguruma, Shin Urai, Shuichi Kitayama, Hironori Bando, Masaaki Yamamoto, Hidenori Fukuoka, Wataru Ogawa, Shin Kaneko, Yutaka Takahashi   +12 more
doaj   +1 more source

Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy

JACC: Basic to Translational Science
Summary: Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM ...
Reo Hata, MD, Shunsuke Funakoshi, MD, PhD, Takeru Makiyama, MD, PhD, Takao Kato, MD, PhD, Megumi Narita, BS, Yasuko Matsumura, MS, Ryoko Hirohata, MS, Yuki Naka, BS, Kazumi Ida, MS, Hiroaki Ito, MD, Akihiko Yoshizawa, MD, PhD, Yasuhito Nannya, MD, PhD, Hironori Haga, MD, PhD, Seishi Ogawa, MD, PhD, Koh Ono, MD, PhD, Takeshi Kimura, MD, PhD, Yoshinori Yoshida, MD, PhD   +16 more
doaj   +1 more source

Lattice and Continuum Modelling of a Bioactive Porous Tissue Scaffold

, 2018
A contemporary procedure to grow artificial tissue is to seed cells onto a porous biomaterial scaffold and culture it within a perfusion bioreactor to facilitate the transport of nutrients to growing cells.
Beliaev, Dmitry, Krause, Andrew L., Van Gorder, Robert A., Waters, Sarah L.   +3 more
core  

Interferons and cell growth control.

Histology and histopathology, 2000
Cytokines modulate cell growth, differentiation, and immune defenses in the vertebrates. Interferons (IFNs) are a unique class of cytokines that stimulate antiviral, antitumor and antigen presentation by inducing the expression of several cellular genes. Recent studies have identified a novel gene regulatory pathway activated by IFNs, which serves as a
openaire   +3 more sources

Study of pharmaceutical industrial problems [PDF]

The growth of a human colon carcinoma cell line (SK-CO-1) and its production of carcinoembryonic antigen (CEA) in monolayer culture and on single layers of glass beads in unit gravity were evaluated.
Pincus, J. H.
core   +1 more source

Corrigendum: The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline

Frontiers in Cell and Developmental Biology, 2021
Yanqing Wu, Yanqing Wu, Yuan Yuan, Chengbiao Wu, Ting Jiang, Beini Wang, Jun Xiong, Peipei Zheng, Yiyang Li, Jingyu Xu, Ke Xu, Yaqian Liu, Xiaokun Li, Jian Xiao   +13 more
doaj   +1 more source

Cell Growth [PDF]

, 2020
openaire   +2 more sources

Identification and Characterization of a Minimal Apoptotic Domain from p53

The Scientific World Journal, 2001
Kevin M. Ryan, Karen H. Vousden
doaj   +1 more source