Results 221 to 230 of about 349,615 (316)

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

Mitochondrial accumulation of GRK2 as a protective mechanism against hypoxia-induced endothelial dysfunction. [PDF]

Cell Death Discov
Gatto C, Rusciano MR, Sorriento D, Di Pietro P, Abate AC, Visco V, Montone N, Mone P, Di Napoli D, Chivasso P, Bruno VD, Valerio V, Poggio P, Iaccarino G, Santulli G, Vecchione C, Carrizzo A, Ciccarelli M.   +17 more
europepmc   +1 more source

Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium

, 2000
Ricardo Pardal, Uwe Ludewig, Julia Garcı́a-Hirschfeld, José López‐Barneo   +3 more
openalex   +1 more source

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Hypoxia- and mechanical stress-induced upregulation of mitochondrial HSP60 is associated with phenotypic switching of pulmonary arterial smooth muscle cells. [PDF]

Cell Stress Chaperones
Liu G, Nie H, Zhang X, Huang ZS, Yoshiura KI, Liu KX, Liu Y, Li TS.   +7 more
europepmc   +1 more source

Tie2 Receptor Expression Is Stimulated by Hypoxia and Proinflammatory Cytokines in Human Endothelial Cells

, 2000
Carsten Willam, Petra Koehne, Jan Steffen Jürgensen, Michael Gräfe, Kay‐Dietrich Wagner, Sebastian Bachmann, Ulrich Frei, Kai‐Uwe Eckardt   +7 more
openalex   +1 more source

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source

Hypoxia upregulate TPM4 expression to strengthen epithelial-mesenchymal transition that promotes lymph node metastasis of papillary thyroid cancer. [PDF]

J Cancer
Li Z, Li F, Jiang X, Li Y, Jia L, Wang X, Liu Y, Jiang R, Zhao K, Pu G, Tian Y, Wang Y, He X.   +12 more
europepmc   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

Influence of Hypoxia on Tumor Heterogeneity, DNA Repair, and Cancer Therapy: From Molecular Insights to Therapeutic Strategies. [PDF]

Cells
Kunachowicz D, Tomecka P, Sędzik M, Kalinin J, Kuźnicki J, Rembiałkowska N.   +5 more
europepmc   +1 more source