Results 1 to 10 of about 679,116 (120)

Are We Ready for Migrastatics?

Cells, 2021
Metastasis accounts for the highest mortality rates in solid tumor cancer patients. However, research and development have neglected this most lethal characteristic and, instead, have concentrated on the hallmarks of cancer that make tumor cells highly ...
Jonathan Solomon, Magdalena Raškova, Daniel Rösel, Jan Brábek, Hava Gil-Henn   +4 more
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Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases

Cells, 2021
Non-receptor tyrosine kinases (NRTKs) are crucial mediators of intracellular signaling and control a wide variety of processes such as cell division, morphogenesis, and motility.
Trishna Saha, Hava Gil-Henn
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Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Nature Communications, 2023
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Chunmei Kuang, Meijuan Xia, Gang An, CuiCui Liu, Cong Hu, Jingyu Zhang, Zhenhao Liu, Bin Meng, Pei Su, Jiliang Xia, Jiaojiao Guo, Yinghong Zhu, Xing Liu, Xuan Wu, Yi Shen, Xiangling Feng, Yanjuan He, Jian Li, Lugui Qiu, Jiaxi Zhou, Wen Zhou   +20 more
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Seeking and Exploring Efficient Ways to Target Cancer

Cells, 2020
Anti-cancer treatments have never been so numerous and so efficient [...]
Tuula Kallunki
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Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance

Nature Communications, 2022
The bone tumour microenvironment plays an essential role in multiple myeloma (MM) development. Here, the authors show that bone collagen degradation provides glycine to support MM progression through glutathione and purine synthesis.
Jiliang Xia, Jingyu Zhang, Xuan Wu, Wanqing Du, Yinghong Zhu, Xing Liu, Zhenhao Liu, Bin Meng, Jiaojiao Guo, Qin Yang, Yihui Wang, Qinglin Wang, Xiangling Feng, Guoxiang Xie, Yi Shen, Yanjuan He, Juanjuan Xiang, Minghua Wu, Gang An, Lugui Qiu, Wei Jia, Wen Zhou   +21 more
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Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187

Cell Death and Disease, 2022
The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1).
Xin Li, Zhiguo Niu, Chen Sun, Shu Zhuo, Huijie Yang, Xiao Yang, Yun Liu, Cheng Yan, Zhongbo Li, Qi Cao, Guimei Ji, Yinlu Ding, Ting Zhuang, Jian Zhu   +13 more
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TAGLN2-Regulated Trophoblast Migration, Invasion and Fusion are Impaired in Preeclampsia

Frontiers in Cell and Developmental Biology, 2022
Preeclampsia (PE) is a serious disease during pregnancy that affects approximately eight million mothers and infants worldwide each year and is closely related to abnormal trophoblast function.
Hao Wang, Hao Wang, Xiaowei Zhang, Xiaowei Zhang, Chunfeng Liu, Chunfeng Liu, Shengfu Chen, Xinyang Liu, Xinyang Liu, Shangrong Fan, Shangrong Fan   +10 more
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Long Non-coding RNA TMEM220-AS1 Suppressed Hepatocellular Carcinoma by Regulating the miR-484/MAGI1 Axis as a Competing Endogenous RNA

Frontiers in Cell and Developmental Biology, 2021
Long non-coding RNAs (lncRNAs) have a considerable regulatory influence on multiple biological processes. Nevertheless, the role of TMEM220-AS1 in hepatocellular carcinoma (HCC) remains unclear.
Cong Cao, Jun Li, Guangzhi Li, Gaoyu Hu, Zhihua Deng, Bing Huang, Jing Yang, Jiequn Li, Jiequn Li, Song Cao   +9 more
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Calpain and oral cancer – A novel approach to detect cancer cell invasion

Indian Journal of Dental Sciences, 2022
Calpain is a Ca2+ dependent non-lysosomal cytosolic and mitochondrial cysteine protease found in tissue and organ specific manner in human being and in other mammals.
Sayani Shome, Shiladitya Sil
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Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation

Cells, 2019
Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and the third cause of cancer-related mortality. Hepatitis C virus (HCV) is the leading cause of chronic hepatitis, which often results in liver fibrosis, cirrhosis, and ...
Liat Ninio, Abraham Nissani, Tomer Meirson, Tom Domovitz, Alessandro Genna, Shams Twafra, Kolluru D. Srikanth, Roba Dabour, Erez Avraham, Ateret Davidovich, Hava Gil-Henn, Meital Gal-Tanamy   +11 more
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