Results 11 to 20 of about 679,265 (269)
Tumor Cell Invasion in Glioblastoma [PDF]
International Journal of Molecular Sciences, 2020 Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark feature of aggressive invasion into the surrounding tissue. Invasive glioblastoma cells escape surgery
Arabel Vollmann-Zwerenz +4 more
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Invasion of Host Cells by Microsporidia [PDF]
Frontiers in Microbiology, 2020 Microsporidia are found worldwide and both vertebrates and invertebrates can serve as hosts for these organisms. While microsporidiosis in humans can occur in both immune competent and immune compromised hosts, it has most often been seen in the immune suppressed population, e.g., patients with advanced HIV infection, patients who have had organ ...
Bing Han +5 more
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Maximizing tumor cell invasion [PDF]
Pigment Cell & Melanoma Research, 2009 The Rho family of proteins, com-prised of Rho, Rac, and Cdc42 is impli-cated actomyosin contractility andmicrotubule arrangement (Ridley, 2001;Scott, 2002). RhoA, B and C activateRho kinase (ROCK), which causes theformation of actin stress fibers by rein-forcing actomysin contractile force.
Pat P, Ongusaha, Sam W, Lee
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Molecular Therapy: Nucleic Acids, 2021 The incidence and mortality of papillary thyroid cancer (PTC) have steadily increased. Although conventional therapies are very effective toward differentiated PTC patients, very limited therapeutic options are applicable to those patients with distant ...
Xiwu Ouyang +7 more
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Autophagy and tumor cell invasion [PDF]
Cell Cycle, 2012 Of the hallmarks of cancer,1 the process of invasion and metastases is arguably the least well-understood and therefore least drugable. Invasion through the extracellular matrix is arguably the critical distinction between carcinoma in situ and carcinoma with metastatic potential.
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Epigenetics & Chromatin, 2019 Background The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA methylation and cancer progression ...
Ling Chen +15 more
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Nature Communications, 2016 The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the ...
Hadir Marei +7 more
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F1000Research, 2023 Many developmental and physiological processes require cells to invade and migrate through extracellular matrix barriers. This specialized cellular behavior is also misregulated in many diseases, such as immune disorders and cancer.
Isabel W. Kenny-Ganzert +2 more
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Frontiers in Oncology, 2021 BackgroundCancer metastasis and recurrence after radiotherapy are the significant causes of poor prognosis in head-neck cancer (HNC). Clinically, it is commonly found that patients with either condition may accompany the outcome of the other.
Guo-Rung You +15 more
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Overview of Poultry Eimeria Life Cycle and Host-Parasite Interactions
Frontiers in Veterinary Science, 2020 Apicomplexan parasites of the genus Eimeria are organisms which invade the intestinal tract, causing coccidiosis, an enteric disease of major economic importance worldwide.
Sara López-Osorio +3 more
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