Results 1 to 10 of about 18,536,823 (334)

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Briefings Bioinform., 2021
Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response.
D. Maeser, Robert F. Gruener, R. Huang
semanticscholar   +1 more source

Culture and multiomic analysis of lung cancer patient-derived pleural effusions revealed distinct druggable molecular types

Scientific Reports, 2022
Malignant pleural effusion (MPE) is an independent determinant of poor prognostic factor of non-small cell lung cancer (NSCLC). The course of anchorage independent growth within the pleural cavity likely reforms the innate molecular characteristics of ...
Ha-Young Seo, Soon-Chan Kim, Woo-lee Roh, Young-Kyoung Shin, Soyeon Kim, Dong-Wan Kim, Tae Min Kim, Ja-Lok Ku   +7 more
doaj   +1 more source

The Curious Case of the HepG2 Cell Line: 40 Years of Expertise

International Journal of Molecular Sciences, 2021
Liver cancer is the third leading cause of cancer death worldwide. Representing such a dramatic impact on our lives, liver cancer is a significant public health concern.
V. Arzumanian, O. Kiseleva, E. Poverennaya   +2 more
semanticscholar   +1 more source

Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses

npj Genomic Medicine, 2022
Multifocal colorectal cancer (CRC) comprises both clonally independent primary tumors caused by inherited predisposition and clonally related tumors mainly due to intraluminal spreading along an intact basement membrane.
Nahyun Jeong, Soon-Chan Kim, Ji Won Park, Seul Gi Park, Ki-Hoan Nam, Ja Oh Lee, Young-Kyoung Shin, Jeong Mo Bae, Seung-Yong Jeong, Min Jung Kim, Ja-Lok Ku   +10 more
doaj   +1 more source

Identification of Mispairing Omic Signatures in Chinese Hamster Ovary (CHO) Cells Producing a Tri-Specific Antibody

Biomedicines, 2023
Monoclonal antibody-based therapy has shown efficacy against cancer, autoimmune, infectious, and inflammatory diseases. Multispecific antibodies (MsAbs), including trispecifics (tsAbs), offer enhanced therapeutic potential by targeting different epitopes.
Maria João Sebastião, Michael Hoffman, José Escandell, Fatemeh Tousi, Jin Zhang, Bruno Figueroa, Christine DeMaria, Patrícia Gomes-Alves   +7 more
doaj   +1 more source

Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses

Advanced Science, 2022
Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of patient‐derived organoids (PDOs)
Soon‐Chan Kim, Ji Won Park, Ha‐Young Seo, Minjung Kim, Jae‐Hyeon Park, Ga‐Hye Kim, Ja Oh Lee, Young‐Kyoung Shin, Jeong Mo Bae, Bon‐Kyoung Koo, Seung‐Yong Jeong, Ja‐Lok Ku   +11 more
doaj   +1 more source

Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models [PDF]

Endocrinology and Metabolism, 2022
The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies.
Min Ji Jeon, Bryan R. Haugen
doaj   +1 more source

Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue

Scientific Data, 2023
Glioblastoma (GBM) is the most lethal intracranial tumor. Sequencing technologies have supported personalized therapy for precise diagnosis and optimal treatment of GBM by revealing clinically actionable molecular characteristics.
Soon-Chan Kim, Young-Eun Cho, Young-Kyoung Shin, Hyeon Jong Yu, Tamrin Chowdhury, Sojin Kim, Kyung Sik Yi, Chi-Hoon Choi, Sang-Hoon Cha, Chul-Kee Park, Ja-Lok Ku   +10 more
doaj   +1 more source

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma.

New England Journal of Medicine, 2021
BACKGROUND The prognosis of patients with early relapsed or refractory large B-cell lymphoma after the receipt of first-line chemoimmunotherapy is poor.
F. Locke, D. Miklos, C. Jacobson, M. Perales, M. Kersten, O. Oluwole, A. Ghobadi, A. Rapoport, J. McGuirk, J. Pagel, J. Muñoz, U. Farooq, T. van Meerten, P. Reagan, A. Sureda, I. Flinn, P. Vandenberghe, K. Song, M. Dickinson, M. Minnema, P. Riedell, L. Leslie, S. Chaganti, Yin Yang, S. Filosto, J. Shah, M. Schupp, C. To, P. Cheng, L. Gordon, J. Westin   +30 more
semanticscholar   +1 more source

PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions

Cells, 2020
The PC12 cell line is one of the most commonly used in neuroscience research, including studies on neurotoxicity, neuroprotection, neurosecretion, neuroinflammation, and synaptogenesis.
B. Wiatrak, A. Kubis-Kubiak, A. Piwowar, E. Barg   +3 more
semanticscholar   +1 more source