, 2023 Our scientists have years of experience at performing gene editing with CRISPR/Cas9, from designing gRNA to transfection and single clone generation. Creative Biogene is offering a series of knockout cell lines developed by CRISPR/Cas9 system. These cell
Marcia Brady
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Development and characterization of a new human hepatic cell line [PDF]
, 2015 The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert +6 more
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Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells. [PDF]
, 1998 Methylation has been shown to play an important role in the down-regulation of oestrogen receptors (ER) in breast cancer cells. One critical question that remains unclear is whether methylation can account for the loss of ER expression in cells derived ...
Chen, Z, Jordan, VC, Ko, A, Yang, J
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Rationalized development of a campus-wide cell line dataset for implementation in the biobank LIMS system at Bioresource center Ghent [PDF]
, 2019 The Bioresource center Ghent is the central hospital-integrated biobank of Ghent University Hospital. Our mission is to facilitate translational biomedical research by collecting, storing and providing high quality biospecimens to researchers. Several of
T'Joen, Veronique +6 more
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Cell line name recognition in support of the identification of synthetic lethality in cancer from text [PDF]
, 2015 Motivation: The recognition and normalization of cell line names in text is an important task in biomedical text mining research, facilitating for instance the identification of synthetically lethal genes from the literature.
Ginter, Filip +5 more
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The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells [PDF]
, 2016 Background: While nanotechnology is advancing rapidly, nanosafety tends to lag behind since general mechanistic insights into cell-nanoparticle (NP) interactions remain rare.
De Smedt, Stefaan +7 more
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Minimum Cell Connection in Line Segment Arrangements [PDF]
, 2017 We study the complexity of the following cell connection problems in segment arrangements. Given a set of straight-line segments in the plane and two points a and b in different cells of the induced arrangement: [(i)] compute the minimum number of ...
Alt, H. +3 more
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Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. [PDF]
, 2013 IntroductionThe purpose of this study is to identify target proteins that may play important functional roles in oral cancer stem-like cells (CSCs) using mass spectrometry-based quantitative proteomics.MethodsSphere-formation assays were performed on ...
Feng, Sizhe +3 more
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. [PDF]
, 2016 Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments
A Basu +45 more
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Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]
, 2013 Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
An, Wenfeng +5 more
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