Results 1 to 10 of about 5,658,707 (210)
Scientific Reports, 2022 Malignant pleural effusion (MPE) is an independent determinant of poor prognostic factor of non-small cell lung cancer (NSCLC). The course of anchorage independent growth within the pleural cavity likely reforms the innate molecular characteristics of ...
Ha-Young Seo +7 more
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npj Genomic Medicine, 2022 Multifocal colorectal cancer (CRC) comprises both clonally independent primary tumors caused by inherited predisposition and clonally related tumors mainly due to intraluminal spreading along an intact basement membrane.
Nahyun Jeong +10 more
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Biomedicines, 2023 Monoclonal antibody-based therapy has shown efficacy against cancer, autoimmune, infectious, and inflammatory diseases. Multispecific antibodies (MsAbs), including trispecifics (tsAbs), offer enhanced therapeutic potential by targeting different epitopes.
Maria João Sebastião +7 more
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Advanced Science, 2022 Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of patient‐derived organoids (PDOs)
Soon‐Chan Kim +11 more
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Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models [PDF]
Endocrinology and Metabolism, 2022 The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies.
Min Ji Jeon, Bryan R. Haugen
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Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue
Scientific Data, 2023 Glioblastoma (GBM) is the most lethal intracranial tumor. Sequencing technologies have supported personalized therapy for precise diagnosis and optimal treatment of GBM by revealing clinically actionable molecular characteristics.
Soon-Chan Kim +10 more
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Effective flow-through polishing strategies for knob-into-hole bispecific antibodies
Bioresources and Bioprocessing, 2022 Bispecific antibodies (bsAbs), though possessing great therapeutic potential, are extremely challenging to obtain at high purity within a limited number of scalable downstream processing steps.
Serene W. Chen +4 more
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Cell line name recognition in support of the identification of synthetic lethality in cancer from text [PDF]
, 2015 Motivation: The recognition and normalization of cell line names in text is an important task in biomedical text mining research, facilitating for instance the identification of synthetically lethal genes from the literature.
Ginter, Filip +5 more
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Bioresources and Bioprocessing, 2022 Bispecific antibodies (bsAbs) are therapeutically promising due to their ability to bind to two different antigens. However, the bsAb byproducts and impurities, including mispaired homodimers, half-antibodies, light chain mispairings, antibody fragments ...
Serene W. Chen +4 more
doaj +1 more source
Frontiers in Veterinary Science, 2021 Osteosarcoma (OSA) represents the most common primary bone tumor in dogs and is characterized by a highly aggressive behavior. Cell lines represent one of the most suitable and reproducible pre-clinical models, and therefore the knowledge of their ...
Cecilia Gola +8 more
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