Results 41 to 50 of about 3,494,106 (354)

Experimental Adaptation of Rotaviruses to Tumor Cell Lines

PLOS ONE, 2016
A number of viruses show a naturally extended tropism for tumor cells whereas other viruses have been genetically modified or adapted to infect tumor cells. Oncolytic viruses have become a promising tool for treating some cancers by inducing cell lysis or immune response to tumor cells. In the present work, rotavirus strains TRF-41 (G5) (porcine), RRV (
Elver Silva, Emiliano Barreto, Orlando Acosta, Rafael Guerrero, Carlos A. Guerrero   +4 more
openaire   +5 more sources

Vandetanib has antineoplastic activity in anaplastic thyroid cancer, in vitro and in vivo [PDF]

, 2018
The antitumor activity of vandetanib [a multiple signal transduction inhibitor including the RET tyrosine kinase, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) receptor (VEGFR), ERK and with antiangiogenic activity ...
Antonelli, Alessandro, Baldini, Enke, Bocci, Guido, Di Desidero, Teresa, Elia, Giusy, Fallahi, Poupak, Ferrari, Silvia Martina, Fioravanti, Anna, La Motta, Concettina, Materazzi, Gabriele, Miccoli, Paolo, Orlandi, Paola, Paparo, Sabrina Rosaria, Patrizio, Armando, Piaggi, Simona, Ragusa, Francesca, Ruffilli, Ilaria, Ulisse, Salvatore   +17 more
core   +2 more sources

Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation

PLoS ONE, 2016
Skeletal metastatic disease is a deleterious consequence of dissemination of tumor cells from numerous primary sites, such as prostate, lung and breast.
Terese Karlsson, M. Lundholm, A. Widmark, E. Persson   +3 more
semanticscholar   +1 more source

RB activation defect in tumor cell lines [PDF]

Proceedings of the National Academy of Sciences, 2002
Activation of the retinoblastoma (RB) protein through dephosphorylation arises in cells upon exit from M phase and in response to environmental stresses, including DNA damage. We provide here for the first time evidence that these responses are co-ordinately affected in a subset of tumor derived cell lines.
Cristina Broceño, Sibylle Mittnacht, Scott Wilkie   +2 more
openaire   +3 more sources

Cross-domain feature disentanglement for interpretable modeling of tumor microenvironment impact on drug response [PDF]

arXiv, 2023
High-throughput screening technology has facilitated the generation of large-scale drug responses across hundreds of cancer cell lines. However, there exists significant discrepancy between in vitro cell lines and actual tumors in vivo in terms of their response to drug treatments, because of tumors comprise of complex cellular compositions and ...
arxiv  

Interactions of asbestos-activated macrophages with an experimental fibrosarcoma [PDF]

, 1983
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect ...
A Ewing, Ames B. N., Cohn Z. A., Davies P., Gabizon A., J M Davis, K Donaldson, K James, Keller R, Lowry 0., Pylev L. N., Raz A., Topping D. C.   +12 more
core   +2 more sources

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

PLoS ONE, 2015
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines ...
Cheryl Carson, Pichai Raman, J. Tullai, Lei Xu, Martin Hénault, E. Thomas, S. Yeola, Jianmin Lao, M. McPate, J. M. Verkuyl, George Marsh, Jason Sarber, Adam Amaral, Scott Bailey, Danuta Lubicka, H. Pham, Nicolette Miranda, Jian Ding, Hai-ming Tang, H. Ju, P. Tranter, N. Ji, P. Krastel, R. Jain, A. Schumacher, J. Loureiro, Elizabeth L. George, Giuliano Berellini, Nathan T. Ross, S. Bushell, G. Erdemli, J. Solomon, Stuart E Dryer   +32 more
semanticscholar   +1 more source

Generation of Luciferase-expressing Tumor Cell Lines

BIO-PROTOCOL, 2018
Murine tumor models have been critical to advances in our knowledge of tumor physiology and for the development of effective tumor therapies. Essential to these studies is the ability to both track tumor development and quantify tumor burden in vivo. For this purpose, the introduction of genes that confer tumors with bioluminescent properties has been ...
Yiping Yang, Xiaopei Huang, Todd V. Brennan, Liwen Lin   +3 more
openaire   +4 more sources

Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]

, 2015
MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M., kouhkan, F., Mobarra, N., Movahed, M., Rad, S.M.A.H., Shafiee, A., Soleimani, M., Soufi-zomorod, M., Tasharrofi, N.   +8 more
core   +2 more sources

Expression of the neural cell adhesion molecule NCAM in endocrine cells [PDF]

, 1989
We examined the expression of the neural cell adhesion molecule NCAM in a number of endocrine tissues of adult rat and in an endocrine tumor cell line. NCAM was found by immunoelectron microscopy to be present on the surface of all endocrine cells in the
Aletsee-Ufrecht, M. C., Grant, N., Gratzl, Manfred, Langley, O. K.   +3 more
core   +1 more source