Results 51 to 60 of about 3,494,106 (354)

Absence of ST7 mutations in tumor-derived cell lines and tumors

Nature Genetics, 2001
The gene ST7 has been proposed as the multi-tissue tumor-suppressor gene (TSG) at chromosome 7q31.1. However, we have sought and failed to detect the truncating mutations reported to exist in this gene.
Hughes, Kate A., Hurlstone, Adam F L, Tobias, Edward S., McFarlane, Robert, Black, Donald M.   +4 more
openaire   +5 more sources

Expression of Tumor Assosiated and Epithelial-mesenchymal Transition Markers in 2d and 3d Cell Cultures of Mcf-7 [PDF]

, 2016
The target effects on the expression of epithelial-mesenchymal transition regulation molecules are promising for cancer therapy, including breast cancer.
Herheliuk, T. (Tetiana), Ostapchenko, L. (Lyudmila), Perepelytsina, O. (Olena), Sydorenko, M. (Mykhailo), Yurchenko, N. (Natalia)   +4 more
core   +2 more sources

First-Line Nivolumab Plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers

Journal of Clinical Oncology, 2019
PURPOSE CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment of advanced/metastatic non–small-cell lung cancer (NSCLC).
N. Ready, M. Hellmann, M. Awad, G. Otterson, M. Gutierrez, J. Gainor, H. Borghaei, J. Jolivet, L. Horn, M. Mates, J. Brahmer, I. Rabinowitz, P. Reddy, J. Chesney, J. Orcutt, D. Spigel, M. Reck, K. O'Byrne, L. Paz-Ares, Wenhua Hu, K. Zerba, Xuemei Li, B. Lestini, W. Geese, J. Szustakowski, G. Green, Han Chang, S. Ramalingam   +27 more
semanticscholar   +1 more source

The Role of Cell Lines in the Study of Neuroendocrine Tumors [PDF]

Neuroendocrinology, 2012
Cell lines originating from neuroendocrine tumors (NETs) represent useful experimental models to assess the control of synthesis and release of different hormones and hormone-like peptides, to evaluate the mechanisms of action of these agents in target tissues at the cellular and subcellular levels, and to study cell proliferation and tumor development,
Hadara Rubinfeld, Ilan Shimon, Simona Grozinsky-Glasberg   +2 more
openaire   +2 more sources

CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. [PDF]

, 2011
Introduction. Sensitive and specific imaging of pancreas cancer are necessary for accurate diagnosis, staging, and treatment. The vast majority of pancreas cancers express the carbohydrate tumor antigen CA19-9. The goal of this study was to determine the
Girgis, Mark D, Kenanova, Vania, McCabe, Katelyn E, Olafsen, Tove, Tomlinson, James S, Wu, Anna M   +5 more
core   +4 more sources

Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy.

Journal of Clinical Oncology, 2018
PURPOSE Merkel cell carcinoma (MCC) is an aggressive skin cancer often caused by the Merkel cell polyomavirus. Clinical trials of programmed cell death-1 pathway inhibitors for advanced MCC (aMCC) demonstrate increased progression-free survival (PFS ...
P. Nghiem, S. Bhatia, E. Lipson, W. Sharfman, R. Kudchadkar, A. Brohl, P. Friedlander, A. Daud, H. Kluger, S. Reddy, B. Boulmay, A. Riker, M. Burgess, B. Hanks, T. Olencki, K. Margolin, Lisa M Lundgren, A. Soni, N. Ramchurren, C. Church, Song Y Park, M. Shinohara, Bob A. Salim, J. Taube, S. Bird, N. Ibrahim, S. Fling, B. Homet Moreno, E. Sharon, M. Cheever, S. Topalian   +30 more
semanticscholar   +1 more source

Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non–Small Cell Lung Cancer

JAMA Oncology, 2020
Key Points Question Does first-line durvalumab treatment with or without tremelimumab improve survival outcomes vs chemotherapy in patients with metastatic non–small cell lung cancer?
N. Rizvi, B. Cho, N. Reinmuth, K. Lee, A. Luft, M. Ahn, M. M. van den Heuvel, M. Cobo, D. Vicente, A. Smolin, V. Moiseyenko, S. Antonia, S. Le Moulec, G. Robinet, R. Natale, J. Schneider, F. Shepherd, Sarayut Lucien Geater, E. Garon, Edward S. Kim, S. Goldberg, K. Nakagawa, R. Raja, B. Higgs, A. Boothman, Luping Zhao, U. Scheuring, P. Stockman, V. Chand, S. Peters   +29 more
semanticscholar   +1 more source

B7h Triggering Inhibits the Migration of Tumor Cell Lines [PDF]

The Journal of Immunology, 2014
Abstract Vascular endothelial cells (ECs) and several cancer cells express B7h, which is the ligand of the ICOS T cell costimulatory molecule. We have previously shown that B7h triggering via a soluble form of ICOS (ICOS-Fc) inhibits the adhesion of polymorphonuclear and tumor cell lines to HUVECs; thus, we suggested that ICOS-Fc may act
Dianzani, Chiara, Minelli, Rosalba, Gigliotti, Casimiro Luca, Occhipinti, Sergio, Giovarelli, Mirella, Conti, Laura, Boggio, Elena, Shivakumar, Yogesh, Baldanzi, Gianluca, Malacarne, Valeria, Orilieri, Elisabetta, Cappellano, Giuseppe, Fantozzi, Roberto, SBLATTERO, DANIELE, Yagi, Junji, Rojo, Josè Maria, Chiocchetti, Annalisa, DIANZANI, Umberto, DE CONTI, LAURA   +18 more
openaire   +5 more sources

Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. [PDF]

, 2020
Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor. Recently, we developed a patient-derived orthotopic xenograft (PDOX) model of adult pleomorphic RMS.
Dry, Sarah M, Hayashi, Katsuhiro, Higuchi, Takashi, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kimura, Hiroaki, Kiyuna, Tasuku, Li, Yunfeng, Miwa, Shinji, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Singh, Shree Ram, Tsuchiya, Hiroyuki, Yamamoto, Norio, Zhao, Ming   +16 more
core  

The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines [PDF]

, 2019
Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP).
Cocchiola, Rossana, de Santi, Maria Margherita, Eufemi, Margherita, Guazzo, Raffaella, Lopreiato, Mariangela, Scandurra, Roberto, Scotto d'Abusco, Anna   +6 more
core   +2 more sources