Results 41 to 50 of about 3,609,152 (355)

Functional implications of the exon 9 splice insert in GluK1 kainate receptors

eLife
Kainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct spatiotemporal expressions have been identified in the brain.
Surbhi Dhingra, Prachi M Chopade, Rajesh Vinnakota, Janesh Kumar   +3 more
doaj   +1 more source

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

Nature Communications, 2017
Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-
Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang   +9 more
doaj   +1 more source

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS

EMBO Molecular Medicine, 2023
ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP‐sensitive potassium (KATP) channels.
Conor McClenaghan, Maya A Mukadam, Jacob Roeglin, Robert C Tryon, Manfred Grabner, Anamika Dayal, Gretchen A Meyer, Colin G Nichols   +7 more
doaj   +1 more source

Ignition and Front Propagation in Polymer Electrolyte Membrane Fuel Cells [PDF]

, 2006
Water produced in a Polymer Electrolyte Membrane (PEM) fuel cell enhances membrane proton conductivity; this positive feedback loop can lead to current ignition.
Benziger, J. B., Chia, E. -S., De Decker, Y., Kevrekidis, I. G.   +3 more
core  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Engineering and Characterization of 3-Aminotyrosine-Derived Red Fluorescent Variants of Circularly Permutated Green Fluorescent Protein

Biosensors
Introducing 3-aminotyrosine (aY), a noncanonical amino acid (ncAA), into green fluorescent protein (GFP)-like chromophores shows promise for achieving red-shifted fluorescence. However, inconsistent results, including undesired green fluorescent species,
Hao Zhang, Xiaodong Tian, Jing Zhang, Hui-wang Ai   +3 more
doaj   +1 more source

Polymer-encased nanodiscs with improved buffer compatibility

Scientific Reports, 2017
Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment without the use of ...
Mariana C. Fiori, Yunjiang Jiang, Guillermo A. Altenberg, Hongjun Liang   +3 more
doaj   +1 more source

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

, 2006
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet, C. C. A. M. Gielen, D. L. Ypey, J. Guckenheimer, J. M. A. M. Kusters, J. M. Cortes, J. D. Murray, O. Aslanidi, T. R. Chay, W. P. M. van Meerwijk   +9 more
core   +1 more source

Fabrication of PEM Fuel Cell Bipolar Plates by Indirect SLS [PDF]

, 2004
The paper presents a new manufacturing technique involving Selective Laser Sintering (SLS) for proton exchange membrane fuel cell (PEMFC) bipolar plate fabrication.
Bourell, David L., Chen, Ssuwei, Wood, Kristin L.   +2 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source