Results 111 to 120 of about 446,721 (287)
Advances in the Study of MG53 in Cardiovascular Disease
International Journal of General Medicine, 2023 Shan-Mei Liu,1,* Qin Zhao,1,* Wen-Jun Li,2 Jian-Quan Zhao1 1Bayannur Hospital Department of Cardiology, Bayannur City, Inner Mongolia, 015000, People’s Republic of China; 2Tangshan Central Hospital, Tangshan, Hebei, 063008, People’s Republic of ...
Liu SM, Zhao Q, Li WJ, Zhao JQ
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Clinical resistance to platinum chemotherapy in ovarian cancer [PDF]
, 2009 Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established.
Newton, C., Newton, C
core
A kinetic model of membrane repair [PDF]
, 1970 Two microelectrodes are inserted into a Xenopus laevis egg. Rectangular current pulses are injected through one microelectrode and the voltage induced across the cell membrane is measured via the second electrode.
Newell Mack +3 more
core +1 more source
Determining the Role of Annexin A6 in Cell Membrane Repair
The FASEB Journal, 2018 All cells are susceptible to stress or contraction‐induced membrane damage; any disruption to the plasma membrane, if left unrepaired, leads to cytoplasmic efflux, ion influx, and ultimately cell death. To maintain homeostasis, cells utilize a highly‐conserved, calcium‐dependent repair system that comprises multiple players that dispatch two ...
Jenny Day +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Injectable Cell-based Tissue Engineered Bone Formulations [PDF]
, 2010 PhDCurrent golden standard therapy for bone repair and regeneration involves the use of auto grafts. Nevertheless, there are many drawbacks associated with auto grafts including donor site morbidity, requirement for an invasive surgery, post-operative
Ahmadi, Raheleh
core
Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response. [PDF]
Nat Commun, 2022 Li Z +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source