Results 121 to 130 of about 446,721 (287)

The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p. [PDF]

, 2012
The degree of fatty acid unsaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, determines membrane fluidity. Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known mechanism governing the ...
de Kroon, Anton I.P.M., Scherer, Max, Tissue Repair, De Smet, C.H., Brouwers, Jos F., Riezman, Howard, Brouwers, J.F.H.M., Dep Biochemie en Celbiologie, Vittone, Elisa, Scherer, M., Houweling, M., De Smet, Cedric H., de Kroon, Toon, Strategic Infection Biology, Sub Membrane Enzymology begr. 01-06-12, Liebisch, G., Vittone, E., Houweling, Martin, Liebisch, Gerhard, Membrane Enzymology   +19 more
core   +1 more source

A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6

Journal of Lipid Research, 2016
The phospholipase A2 (PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes.
Aron B. Fisher, Chandra Dodia, Elena M. Sorokina, Haitao Li, Suiping Zhou, Tobias Raabe, Sheldon I. Feinstein   +6 more
doaj   +1 more source

The cell membrane repair protein MG53 modulates transcription factor NF-κB signaling to control kidney fibrosis. [PDF]

Kidney Int, 2022
Li H, Duann P, Li Z, Zhou X, Ma J, Rovin BH, Lin PH.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Tissue engineering for total meniscal substitution : Animal study in sheep model [PDF]

, 2008
Objective: The aim of the study was to investigate the use of a novel hyaluronic acid/polycaprolactone material for meniscal tissue engineering and to evaluate the tissue regeneration after the augmentation of the implant with expanded autologous ...
Salter, Donald M., Ambrosio L., Matilde Tschon, Nehrer S., Donald M. Salter, Chiari, Catharina, Enrico Tognana, Martin, Ivan, Maurilio Marcacci, Chiari C., Tognana E., Tschon, Matilde, Fini M., Marco Delcogliano, Kon, Elizaveta, Milena Fini, Fini, Milena, Tognana, Enrico, Catharina Chiari, Salter D. M., Martin I., Plasenzotti R., Luigi Ambrosio, Roberto Plasenzotti, Tschon M., Stefan Nehrer, Ivan Martin, Plasenzotti, Roberto, Elizaveta Kon, Nehrer, Stefan, Marcacci, Maurilio, Delcogliano, Marco, Ambrosio, Luigi   +32 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Microvesicle shedding and lysosomal repair fulfill divergent cellular needs during the repair of streptolysin O-induced plasmalemmal damage.

PLoS ONE, 2014
Pathogenic bacteria secrete pore-forming toxins that permeabilize the plasma membrane of host cells. Nucleated cells possess protective mechanisms that repair toxin-damaged plasmalemma.
Alexander P Atanassoff, Heidi Wolfmeier, Roman Schoenauer, Andrea Hostettler, Avi Ring, Annette Draeger, Eduard B Babiychuk   +6 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source