Results 131 to 140 of about 8,672,364 (340)

Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities [PDF]

, 2004
The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of ...
P.J. Nelson, Belen Vicente, A., R. Djafarzadeh, Mojaat, A., Nelson, P. J., Djafarzadeh, R., Lüttichau, I. von, I. von Lüttichau, A. Belen Vicente, A. Mojaat   +9 more
core   +1 more source

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

Acta Pharmaceutica, 2018
Our previous reports showed that the cyclic-AMP-response element-binding protein (CREB) served as a proto-oncogene in the process of tumorigenesis and mediated the growth and metastatic activity of renal cancer cells.
Huang Shuaishuai, Cui Pinger, Lin Shuangxia, Yao Xuping, Wang Xue, Ren Yu, Weng Guobin   +6 more
doaj   +1 more source

Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition. [PDF]

ACS Med Chem Lett, 2022
Zhu TY, Wu XT, Chen C, Liu XQ, Zhu L, Luo JG, Kong LY.   +6 more
europepmc   +1 more source

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

Cancer Cell, 2009
SUMMARY Both pro- and anti-oncogenic properties have been attributed to EphA2 kinase. We report that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion.
H. Miao, Da-Qiang Li, A. Mukherjee, Hong Guo, A. Petty, Jennifer L. Cutter, J. Basilion, J. Sedor, Jiong Wu, D. Danielpour, A. Sloan, M. Cohen, Bingcheng Wang   +12 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.

PLoS ONE, 2012
Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Role for Drosophila IAP1-Mediated Caspase Inhibition in Rac-Dependent Cell Migration [PDF]

, 2004
Border cell migration in the Drosophila ovary is a relatively simple and genetically tractable model for studying the conversion of epithelial cells to migratory cells.
Montell, Denise J, Geisbrecht, Erika R
core   +1 more source

Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer.

PLoS ONE, 2012
Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms.
Xiao-Feng Le, Maria I Almeida, Weiqun Mao, Riccardo Spizzo, Simona Rossi, Milena S Nicoloso, Shu Zhang, Yun Wu, George A Calin, George A Calin, Robert C Bast   +10 more
doaj   +1 more source

Inhibition of Matrix Metalloproteinase 14 (MMP-14)-mediated Cancer Cell Migration*

Journal of Biological Chemistry, 2011
Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane-anchored MMP, in particular, is closely associated with these processes.
K. Zarrabi, A. Dufour, Jian Li, Cem Kuscu, Ashleigh Pulkoski-Gross, J. Zhi, You-Jun Hu, N. Sampson, S. Zucker, Jian Cao   +9 more
semanticscholar   +1 more source