Results 51 to 60 of about 8,672,364 (340)

Enhancing intracellular reactive oxygen species, apoptosis, and wound healing activities of Benjakul in cholangiocarcinoma [PDF]

Journal of HerbMed Pharmacology
Introduction: Cholangiocarcinoma (CCA) is an aggressive malignancy of the biliary tract with limited treatment options and a poor prognosis. Current therapies, such as gemcitabine and cisplatin, are associated with notable side effects and limited ...
Sutthiwan Janthamala, Saranporn Pornpiphat, Anchalee Techasen, Malinee Thanee, Supaporn Wisungre, Sumalin Deechan, Nawarat Meechai, Phakamas Paratang, Kunyarat Duenngai   +8 more
doaj   +1 more source

Cancer-associated mesothelial cell–derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis

JCI Insight, 2023
Ovarian cancer (OvCa) preferentially metastasizes in association with mesothelial cell–lined surfaces. We sought to determine if mesothelial cells are required for OvCa metastasis and detect alterations in mesothelial cell gene expression and cytokine ...
Preety Bajwa, Kasjusz Kordylewicz, Agnes Bilecz, Ricardo R. Lastra, Kristen Wroblewski, Yuval Rinkevich, Ernst Lengyel, Hilary A. Kenny   +7 more
doaj   +1 more source

CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation

Cancer Medicine, 2021
The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang   +4 more
doaj   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
Haastert, Peter J.M. van,, Peter J M van Haastert, van Haastert, Peter J. M., van Haastert, Peter J.M., Matthew P. Neilson, Douwe M Veltman, Webb, Steven D., Insall, Robert H., Webb, Steven D.,, Neilson, Matthew P.,, Neilson, Matthew P., Matthew P Neilson, Douwe M. Veltman, Peter J. M. van Haastert, Insall, Robert H.,, Steven D Webb, Webb, Steven, Robert H Insall, John A. Mackenzie, Mackenzie, John A.,, John A Mackenzie, Veltman, Douwe M.,, Mackenzie, John A., Veltmahn, Douwe M., Veltman, Douwe M., Steven D. Webb, Robert H. Insall   +26 more
core   +5 more sources

GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition [PDF]

Brazilian Journal of Medical and Biological Research
Previous studies show that glycogen synthase kinase 3β (GSK3B) plays an important role in tumorigenesis. However, its role in cervical cancer is unclear.
Yanhong Zheng, Yang Yang, Weiyan Zhu, Ruhao Liu, Aodong Liu, Runfeng Zhang, Weixing Lei, Shifeng Huang, Yongzhu Liu, Qinglan Hu   +9 more
doaj   +1 more source

Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]

, 2012
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Schwarz, Kerstin, Komor, Martina, Aschenbrenner, Frank, Hofmann, Wolf-Karsten, Bug, Gesine, Ruthardt, Martin, Kampfmann, Manuela, Henschler, Reinhard, Rüster, Brigitte Inge   +8 more
core   +1 more source

Computational Modeling of Single-Cell Migration::The Leading Role of Extracellular Matrix Fibers [PDF]

, 2012
Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as
Schlüter, Daniela K., Ramis-Conde, Ignacio, Chaplain, Mark A. J., Chaplain, Mark A.J., Schlueter, Daniela K.   +4 more
core   +1 more source

Dysregulation of the Mammalian Target of Rapamycin and p27Kip1 Promotes Intimal Hyperplasia in Diabetes Mellitus

Pharmaceuticals, 2013
The proliferation and migration of vascular smooth muscle cells (VSMCs) in the intima of an artery, known as intimal hyperplasia, is an important component of cardiovascular diseases.
Thomas Cooper Woods
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

eLife
Collective cell migration is fundamental for the development of organisms and in the adult for tissue regeneration and in pathological conditions such as cancer.
Julian JA Hoving, Elizabeth Harford-Wright, Patrick Wingfield-Digby, Anne-Laure Cattin, Mariana Campana, Alex Power, Toby Morgan, Erica Torchiaro, Victor Quereda, Alison C Lloyd   +9 more
doaj   +1 more source