Results 71 to 80 of about 8,672,364 (340)

MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA. [PDF]

PLoS ONE, 2014
The loss of microRNA-122 (miR-122) expression is strongly associated with increased invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however, the underlying mechanisms remain poorly understood.
Sheng-Chun Wang, Xiao-Lin Lin, Jing Li, Ting-Ting Zhang, Hui-Yan Wang, Jun-Wen Shi, Sheng Yang, Wen-Tao Zhao, Rao-Ying Xie, Fang Wei, Yu-Juan Qin, Lin Chen, Jie Yang, Kai-Tai Yao, Dong Xiao   +14 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Studying fibroblast growth factor (FGF) mediated cell migration in "Drosophila" larval air sacs [PDF]

, 2005
Invertebrates and vertebrates use FGF signaling in many developmental processes. Mesoderm formation, limb outgrowth but also the development of the vascular system and the lung rely on FGF ligands.
Cabernard, Clemens
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review. [PDF]

FEBS Open Bio
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Azevedo ML, Hall KC, Dos Santos Fernandez M, Corrêa GP, Lund RG.   +4 more
europepmc   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Anti-metastatic Potential of Amide-linked Local Anesthetics: Inhibition of Lung Adenocarcinoma Cell Migration and Inflammatory Src Signaling Independent of Sodium Channel Blockade

Anesthesiology, 2012
Background: Retrospective analysis of patients undergoing cancer surgery suggests the use of regional anesthesia may reduce cancer recurrence and improve survival. Amide-linked local anesthetics have antiinflammatory properties, although the mechanism of
T. Piegeler, E. Gina Votta-Velis, Guoquan Liu, Aaron T. Place, D. E. Schwartz, B. Beck-Schimmer, R. Minshall, A. Borgeat   +7 more
semanticscholar   +1 more source

Inhibition of growth and migration of cholangiocarcinoma cells by pamidronate

Experimental and Therapeutic Medicine, 2019
Pamidronate has been hypothesized to effectively inhibit cancer cell growth and metastasis in bone tissue. Furthermore, pamidronate (Pami) exerts various direct effects against several cancer cell types, including growth and migration. The present study aimed to determine the underlying mechanism of Pami's effect on the proliferation and migration of ...
Buranrat, Benjaporn, Prawan, Auemduan, Senggunprai, Laddawan, Kukongviriyapan, Veerapol   +3 more
openaire   +3 more sources

Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Osteosarcoma is a malignant tumor associated with high mortality; however, no effective therapies for the disease have been developed. Several studies have focused on elucidating the pathogenesis of osteosarcoma and have aimed to develop novel therapies for the disease. Quercetin is a vital dietary flavonoid that has been shown to have
Haifeng Lan, Wei Hong, Pan Fan, Dongyang Qian, Jianwei Zhu, Bo Bai   +5 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The immunosuppressant Protosappanin A diminished recipient T cell migration into allograft via inhibition of IP-10 in rat heart transplant.

PLoS ONE, 2014
The immunosuppressant Protosappanin A (PrA), isolated from the medicinal herb, promotes cardiac allograft survival, diminishes inflammatory cell infiltration, and inhibits interferon γ-induced protein 10 kDa (IP-10) mRNA expression in rats cardiac grafts.
Maomao Zhang, Jieqiong He, Jingbo Hou, Jian Wu, Meng Sun, Jinjin Cui, Jiangtian Tian, Miaomiao Jiang, Bo Yu   +8 more
doaj   +1 more source