Results 91 to 100 of about 8,672,364 (340)

Inhibition of chromatin condensation disrupts planar cell migration

Nucleus
Cell migration involves the actin cytoskeleton, and recently recognized nuclear involvement. In this study, we explore the impact of chromatin remodeling on cell migration using NIH 3T3 cells and a scratch wound assay subjected to pharmacological ...
Jack Forman, Briar Hine, Samantha Kaonis, Soham Ghosh   +3 more
doaj   +1 more source

Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices

BMC Cell Biology, 2012
Background The behaviour of tumour cells depends on factors such as genetics and the tumour microenvironment. The latter plays a crucial role in normal mammary gland development and also in breast cancer initiation and progression.
Raviraj Vanisri, Fok Sandra, Zhao Jifei, Chien Hsin-Ya, Lyons J, Thompson Erik W, Soon Lilian   +6 more
doaj   +1 more source

Indacaterol inhibits collective cell migration and IGDQ-mediated single cell migration in metastatic breast cancer MDA-MB-231 cells

Cell Communication and Signaling, 2023
Summary Metastasis is the main cause of deaths related to breast cancer. This is particular the case for triple negative breast cancer. No targeted therapies are reported as efficient until now.
Sophie Ayama-Canden, Rodolfo Tondo, Martha Liliana Pineros Leyton, Noëlle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Aude Sauvage, Tijani Tabarrant, Stéphane Lucas, Davide Bonifazi, Carine Michiels   +11 more
doaj   +1 more source

Annexin-1-mediated Endothelial Cell Migration and Angiogenesis Are Regulated by Vascular Endothelial Growth Factor (VEGF)-induced Inhibition of miR-196a Expression*

Journal of Biological Chemistry, 2012
Background: Annexin-A1 is an important regulator of VEGF-mediated endothelial cell migration and angiogenesis. Results: We found that miR-196a targets Annexin-A1 to inhibit VEGF-mediated cell migration and angiogenesis.
Anne-Laure Pin, François Houle, P. Fournier, M. Guillonneau, E. Paquet, Martin J. Simard, I. Royal, J. Huot   +7 more
semanticscholar   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Shifting the optimal stiffness for cell migration

Nature Communications, 2017
Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal.
Benjamin L. Bangasser, Ghaidan A Shamsan, Clarence E Chan, Kwaku N. Opoku, E. Tüzel, Benjamin W Schlichtmann, Jesse Kasim, Benjamin Fuller, B. R. McCullough, S. Rosenfeld, D. Odde   +10 more
semanticscholar   +1 more source

Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes [PDF]

Advanced Healthcare Materials, 2015
Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death.
García Hevia, Lorena, Valiente Barroso, Rafael, Fernández Luna, José Luis, Flahaut, Emanuel, Rodríguez Fernández, Lidia, Villegas Sordo, Juan Carlos, González Gómez, Jesús Antonio, López Fanarraga, Mónica   +7 more
openaire   +5 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Ras and its effectors: a double role in regulating cell migration [PDF]

, 2010
Within this work, time-lapse microscopy and quantitative analysis of motion parameters were used to characterize Ras regulation of the phenomena determining directional cell migration. The behaviour of NIH3T3 and NIHRasV12 fibroblasts, expressing RasV12,
Ferrari, Maria Carla
core   +1 more source

Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase

BMC Cancer, 2022
Background We have previously reported that a new intronless gene for casein kinase 2α (CK2α), CSNK2A3, is expressed in human cells. The promoter of the well-known CK2α, CSNK2A1, displays characteristics of a housekeeping gene, whereas CSNK2A3 has a ...
Adhikarimayum Lakhikumar Sharma, Puyam Milan Meitei, Takhellambam Chanu Machathoibi, Naorem Tarundas Singh, Thiyam Ramsing Singh, Lisam Shanjukumar Singh   +5 more
doaj   +1 more source