Results 61 to 70 of about 8,672,364 (340)

Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and RepairSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and Aims: Gut bacteria-derived short-chain fatty acids (SCFAs) play crucial roles in the maintenance of intestinal homeostasis. However, how SCFAs regulate epithelial turnover and tissue repair remain incompletely understood. In this study, we
Anthony J. Bilotta, Chunyan Ma, Wenjing Yang, Yanbo Yu, Yu Yu, Xiaojing Zhao, Zheng Zhou, Suxia Yao, Sara M. Dann, Yingzi Cong   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Regulation of cell migration by dynamic microtubules [PDF]

, 2011
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina, Anne Straube, Kaverina, Irina, Straube, Anne   +3 more
core   +1 more source

A Novel Src Kinase Inhibitor, M475271, Inhibits VEGF-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration

Journal of Pharmacological Sciences, 2005
Vascular endothelial growth factor (VEGF) was reported to be a potent proangiogenic factor that plays a pivotal role in both physiological and pathological angiogenesis.
Nermin Ali, Masanori Yoshizumi, Yoshiko Fujita, Yuki Izawa, Yasuhisa Kanematsu, Keisuke Ishizawa, Koichiro Tsuchiya, Seiji Yano, Saburo Sone, Toshiaki Tamaki   +9 more
doaj   +1 more source

ROCK inhibition activates MCF-7 cells. [PDF]

PLoS ONE, 2014
Dormant carcinoma cancer cells showing epithelial characteristics can be activated to dissipate into the surrounding tissue or organs through epithelial-mesenchymal transition (EMT).
Seungwon Yang, Hyun-Man Kim
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mesenchymal cell invasion requires cooperative regulation of persistent microtubule growth by SLAIN2 and CLASP1 [PDF]

, 2016
Microtubules regulate signaling, trafficking, and cell mechanics, but the respective contribution of these functions to cell morphogenesis and migration in 3D matrices is unclear.
Noordstra, Ivar, Katrukha, Eugene A., Derksen, Patrick W. B., Katrukha, Eugene A, van Amersfoort, Miranda, Ter Hoeve, Natalie D, Celbiologie, Bouchet, Benjamin P, Derksen, Patrick W B, Dogterom, Marileen, Ammon, York-Christoph, Bouchet, Benjamin P., Hodgson, Louis, Sub Cell Biology, Akhmanova, Anna, ter Hoeve, Natalie D.   +15 more
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes [PDF]

, 2009
In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)-mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription factors, and also controls T ...
Feijoo, C., Sinclair, L.V., Sinclair, Linda V., David K. Finlay, Waugh, C.M., Hagenbeek, Thijs J., Doreen A. Cantrell, Cantrell, Doreen A., Waugh, Caryll M., Hagenbeek, T.J., Carmen Feijoo, Cantrell, D.A., Feijoo, Carmen, Finlay, D.K., Hergen Spits, Spits, Hergen, Spits, H., Linda V. Sinclair, Finlay, David K., Caryll M. Waugh, Thijs J. Hagenbeek   +20 more
core   +2 more sources