Results 121 to 130 of about 4,939,783 (282)

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Nucleophosmin: A Nucleolar Phosphoprotein Orchestrating Cellular Stress Responses

Cells
Nucleophosmin (NPM1) is a key nucleolar protein released from the nucleolus in response to stress stimuli. NPM1 functions as a stress regulator with nucleic acid and protein chaperone activities, rapidly shuttling between the nucleus and cytoplasm.
Mohamed S. Taha, Mohammad Reza Ahmadian
doaj   +1 more source

Latin America's First Active and Intelligent Packaging for Organ Transportation

Packaging Technology and Science, EarlyView.
The graphical abstract features Latin America's first active and intelligent packaging for organ transportation (EMAIS‐SR). The image illustrates the device alongside its core features: active temperature control, real‐time monitoring, autonomous battery‐powered operation and biological safety.
Sibele Maria Schuantes‐Paim, Renata Fabiana Leite, Victor Arayama Cruz, Vanessa Ayres Carneiro Gonçalves, Júlia Karini da Silva Araujo, Karoline Sabrina de Carvalho Gomes, Luciana Chelotti Cardim Perillo, Graciana Maria de Moraes Coutinho, Eliana Cavalari Teraoka, Adriana Aparecida Carbonel, José Homero Soares, Manuel de Jesus Simões, Selma Ferrer, Ari Nelson Rodrigues Costa, Ana Paula Reis Nolêtto, Leandro Moriyama Konatu, Murched Omar Taha, André Ibrahim David, Janine Schirmer, Bartira de Aguiar Roza   +19 more
wiley   +1 more source

Ядерно-ядрышковая изменчивость семенного потомства сосны меловой урожаев разных лет в заповеднике «Меловая флора»

Фактори експериментальної еволюції організмів, 2014
Aims. Analysis of nuclear organizer activity in seed progeny of one and the same plant group in different years within a natural population of Pinus sylvestris L. var. cretacea Kalenicz. ex Kom. Methods.
И. И. Коршиков, Я. Г. Мильчевская, Ю. А. Ткачева, Е. В. Лаптева   +3 more
doaj  

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates

Small, EarlyView.
De novo designed multidomain peptides (MDPs) were used to explore how molecular ordering influences peptide phase behavior. MDPs containing partially folded β‐sheets were found to form biomolecular condensates. This work introduces a new design principle for condensate formation and expand the design space beyond conventional intrinsically disordered ...
Debdatta Das, Jenny N. Nguyen, Navneet Sahoo, Chuanye Xiong, Haritha Asokan‐Sheeja, Yan Chang, Raniyah Ali, Eleanor D. Smith, Chad A. Brautigam, Yi Hong, Zui Pan, Peng Tao, He Dong   +12 more
wiley   +1 more source

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, EarlyView.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

HS‐AFM Reveals Hierarchical RNA Folding Driving Condensate Assembly and Material States

Small, EarlyView.
High‐speed atomic force microscopy reveals the nanoscale pathway of RNA condensate formation, from individual RNA folding to higher‐order assembly. Quantitative analyses of fusion dynamics and nanomechanical properties distinguish liquid‐like poly A condensates from solid‐like total RNA assemblies, providing a direct link between RNA self‐assembly and ...
S. M. Neaz Mahmud, Kenichi Umeda, Tamoghna Das, Nadia Shoukat, Noriyuki Kodera, Hanae Sato   +5 more
wiley   +1 more source

The nucleus-nucleolus polymorphism in seeds of marginal populations of four conifer species

Фактори експериментальної еволюції організмів, 2013
Aims. Comparative analysis of nucleus-nucleolus polymorphism in marginal populations of four conifer species. Methods. Nucleoli staining with AgNO3 in interphase cells of seedlings. Results.
I. I. Korshikov, Yu. A. Tkachova, H. V. Lapteva, Ya. H. Milchevska   +3 more
doaj