Results 171 to 180 of about 1,388,935 (350)

Towards Understanding Long COVID: SARS-CoV-2 Strikes the Host Cell Nucleus. [PDF]

Pathogens, 2023
Lafon-Hughes L.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration [PDF]

, 2019
Zheng Li, Xin Chen, Yuming Zhong, Shugang Li, Matthew T.V. Chan, William Ka Kei Wu   +5 more
openalex   +1 more source

Single nucleus RNASeq profiling of mouse lung: reduced dissociation bias and improved detection of rare cell types compared with single cell RNASeq [PDF]

, 2020
Jeffrey R. Koenitzer, Hao Wu, Jeffrey J. Atkinson, Steven L. Brody, Benjamin D. Humphreys   +4 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A Versatile Micromanipulation Apparatus for Biophysical Assays of the Cell Nucleus. [PDF]

Cell Mol Bioeng, 2022
Currey ML, Kandula V, Biggs R, Marko JF, Stephens AD.   +4 more
europepmc   +1 more source

Somatostatin and Corticotrophin Releasing Hormone Cell Types Are a Major Source of Descending Input From the Forebrain to the Parabrachial Nucleus in Mice [PDF]

, 2014
abdulrahman magableh, R. Lundy
openalex   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Signatures in in vitro infection of NSC-34 mouse neurons and their cell nucleus with Rickettsia helvetica. [PDF]

BMC Microbiol, 2023
Kask L, Påhlson C, Staxäng K, Nilsson K.   +3 more
europepmc   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy [PDF]

, 2018
Changgui Shi, Huiqiao Wu, Di Du, Hee‐Jeong Im, Ying Zhang, Bo Hu, Huajiang Chen, Xinwei Wang, Yang Liu, Peng Cao, Ye Tian, Xiaolong Shen, Rui Gao, André J. van Wijnen, Xiaojian Ye, Y. Edward Wen   +15 more
openalex   +1 more source