Results 161 to 170 of about 908,709 (307)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

A Versatile Micromanipulation Apparatus for Biophysical Assays of the Cell Nucleus. [PDF]

Cell Mol Bioeng, 2022
Currey ML, Kandula V, Biggs R, Marko JF, Stephens AD.   +4 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Signatures in in vitro infection of NSC-34 mouse neurons and their cell nucleus with Rickettsia helvetica. [PDF]

BMC Microbiol, 2023
Kask L, Påhlson C, Staxäng K, Nilsson K.   +3 more
europepmc   +1 more source

Changes in the human nuclear chromatin induced by ultra wideband pulse irradiation

Open Life Sciences, 2009
Shckorbatov Yuriy, Pasiuga Vladimir, Kolchigin Nicolai, Batrakov Dmitry, Kazansky Oleg, Kalashnikov Vladimir   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Amphiphiles Formed from Synthetic DNA-Nanomotifs Mimic the Stepwise Dispersal of Transcriptional Clusters in the Cell Nucleus. [PDF]

Nano Lett, 2023
Tschurikow X, Gadzekpo A, Tran MP, Chatterjee R, Sobucki M, Zaburdaev V, Göpfrich K, Hilbert L.   +7 more
europepmc   +1 more source

E-MEXP-2488 - Transcription profiling of human nucleus pulposus vs articular cartilage cell types

, 2010
Human nucleus pulposus cell vs articular ...
Division of Cell Matrix Biology & Regenerative Medicine (L5), Richardson, Stephen; id_orcid   +1 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Centromeres and telomeres as rheological probes of the human cell nucleus. [PDF]

Biophys J
Clavijo AS, Ionov S, Zidovska A.
europepmc   +1 more source