Results 181 to 190 of about 1,388,881 (305)

BLoss-DDNet: bending loss and dual-task decoding network for overlapping cell nucleus segmentation of cervical clinical LBC images. [PDF]

Front Artif Intell
Yang G, Chen Z, Guo P, Ma J, Huang J, Jin C, Yang X, Zhao K, Wang Y, Gao Q, Liu C, Wu T, Li Y, Guo Y, Zheng J, Cai X, Yang Y.   +16 more
europepmc   +1 more source

Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin. [PDF]

Phys Rev Lett, 2021
Zhang Y, Lee DSW, Meir Y, Brangwynne CP, Wingreen NS.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Precision and Accuracy in Quantitative Measurement of Gene Expression from Single-cell/nucleus RNA Sequencing Data. [PDF]

Genomics Proteomics Bioinformatics
Dai R, Zhang M, Chu T, Kopp R, Zhang C, Liu K, Wang Y, Wang X, Chen C, Liu C.   +9 more
europepmc   +1 more source

The effects of measurement parameters on the cancerous cell nucleus characterisation by atomic force microscopy in vitro. [PDF]

J Microsc, 2022
Zhu J, Tian Y, Yan J, Hu J, Wang Z, Liu X.   +5 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome. [PDF]

Nat Commun
Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB, Wang H, Wai CM, Agrawal V, Dunton CL, Duan C, Jiang B, Backman V, He TC, Reid RR, Luo Y, Ameer GA.   +20 more
europepmc   +1 more source

Modeling stem cell nucleus mechanics using confocal microscopy. [PDF]

Biomech Model Mechanobiol, 2021
Kennedy Z, Newberg J, Goelzer M, Judex S, Fitzpatrick CK, Uzer G.   +5 more
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Interplay of chromatin organization and mechanics of the cell nucleus. [PDF]

Biophys J
De Corato M, Gomez-Benito MJ.
europepmc   +1 more source